EUROTAU: Reflections on the Status Quo

EUROTAU: Reflections on the Status Quo

​​​​​​​Editors: Werner Paulus and Johannes Attems

Acta Neuropathologica Communications is pleased to present a series of articles from the first EUROTAU meeting in Europe.

EUROTAU provides a forum for promoting ambitious, innovative, multi-national and multi-disciplinary collaborative research projects, that: i) combine experimental approaches from fundamental, pre-clinical and/or clinical with computational approaches; ii) perform network analyses in different Tauopathies to elucidate the underlying mechanisms that are common as well as those that are different between them, and iii) will add value to existing research by analyzing diseases across traditional clinical boundaries, thereby gaining deeper understanding of the patho-physiological mechanisms of these disorders.  

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The editors declare that they have no competing interests. This series is now closed.

1. Content Type:Review

   What is the evidence that tau pathology spreads through prion-like propagation?

   Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propaga...

   Authors:Amrit Mudher, Morvane Colin, Simon Dujardin, Miguel Medina, Ilse Dewachter, Seyedeh Maryam Alavi Naini, Eva-Maria Mandelkow, Eckhard Mandelkow, Luc Buée, Michel Goedert and Jean-Pierre Brion

   Citation:Acta Neuropathologica Communications 2017 5:99

   Published on: 19 December 2017

   • ViewFull Text
    
   • ViewPDF
2. Content Type:Research

   Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions

   Microtubule-associated protein tau aggregates constitute the characteristic neuropathological features of several neurodegenerative diseases grouped under the name of tauopathies. It is now clear that the proc...

   Authors:Marta Sidoryk-Wegrzynowicz, Yannick N. Gerber, Miriam Ries, Magdalena Sastre, Aviva M. Tolkovsky and Maria Grazia Spillantini

   Citation:Acta Neuropathologica Communications 2017 5:89

   Published on: 29 November 2017

   • ViewFull Text
    
   • ViewPDF
3. Content Type:Review

   Atypical, non-standard functions of the microtubule associated Tau protein

   Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau’s role in microtubule stability and regulation, as well as on the neuropathological cons...

   Authors:Ioannis Sotiropoulos, Marie-Christine Galas, Joana M. Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher and Luc Buee

   Citation:Acta Neuropathologica Communications 2017 5:91

   Published on: 29 November 2017

   • ViewFull Text
    
   • ViewPDF
4. Content Type:Letter To The Editor

   EuroTau: towing scientists to tau without tautology

   Authors:Amrit Mudher, Jean-Pierre Brion, Jesus Avila, Miguel Medina and Luc Buée

   Citation:Acta Neuropathologica Communications 2017 5:90

   Published on: 29 November 2017

   • ViewFull Text
    
   • ViewPDF