Venous thromboembolism :: Public Health Genomics Knowledge Base (v1.2)

Public Health Genomics Knowledge Base (v1.2)

New CDC Blog Post: Genetic Testing for Thrombophilia

This week, we highlight a new CDC blog post entitled:“The Appropriateness and Cost of Thrombophilia Panel Testing: It’s Complicated” 

For additional information on  genomics and venous thromboembolism, check out the Public Health Genomics Knowledge Base

Last Updated: Dec 15, 2016

• The Appropriateness and Cost of Thrombophilia Panel Testing: It’s Complicated
  S Bowen et al, CDC Blog Post, December 15, 2016
• Having Surgery? Take Steps to Prevent Blood Clots!
  C Hooper, HHS Blog Post, August 22, 2016
• Stop the Clot, Spread the Word 
  New Campaign Materials on Blood Clots and Hospitalization
• African Ancestry and Dangerous Blood Clots 
  R Lewis, PLOS Blogs, June 30, 2016
• CDC Challenge Winners!
  CDC champions for success in preventing healthcare-associated blood clots.
• Deep Vein Thrombosis and Pulmonary Embolism (DVT/PE) are often underdiagnosed and serious, but preventable medical conditions. 
• Personal Stories of Deep Vein Thrombosis
  CDC Flickr Album
• Blood Clot: It Happened to Her, Don’t Let It Happen to You
  Craig Hooper, HHS Blog post, October 20, 2015
• Thrombophilia and varicella zoster in children.
  Ferrara Mara et al. Hematology 2013 Mar (2) 119-22
• ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.
  Published on 2013 by American College of Medical Genetics and Genomics
• Recommendations from the EGAPP Working Group: routine testing for Factor V Leiden (R506Q) and prothrombin (20210G>A) mutations in adults with a history of idiopathic venous thromboembolism and their adult family members.
  Published on 2012 by Evaluation of Genomic Applications in Practice and Prevention
• Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism.
  Lewis Deborah A et al. Thromb. Res. 2015 Apr 135(4) 659-65
• Family history of myocardial infarction is a risk factor for venous thromboembolism among whites but not among blacks.
  Mili Fatima D et al. Clin. Appl. Thromb. Hemost. 19(4) 410-7
• Increased risk of venous thromboembolism is associated with genetic variation in heme oxygenase-1 in Blacks.
  Bean Christopher J et al. Thromb. Res. 2012 Dec 130(6) 942-7
• JAMA Patient Page: Deep Vein Thrombosis
  AE Thompson, JAMA May 26, 2015

• CDC Information (6)
• CDC-Authored Pub (3)

• Human (2)
• Pathogen (0)

• Human (452)
• Pathogen (0)

• Human (11)
• Pathogen (0)

• Guidelines (2)
• Tier Table (0)
• Synthesis (3)

Relevant Resources

• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB