Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer R Pearlman et al, JAMA Oncology, December 15, 2016

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Last Posted: Dec-16-2016 7AM

 Lynch Syndrome expanded expanded

Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer
R Pearlman et al, JAMA Oncology, December 15, 2016

Universal Genetic Testing for Younger Patients With Colorectal Cancer
E Vilar et al, JAMA Oncology, December 15, 2016

Towards value-based universal Lynch syndrome identification in endometrial cancer patients.
Dottino Joseph A et al. Gynecologic oncology 2016 Dec 143(3) 451-452

More information on this topic

Last Updated: Dec 15, 2016

• Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer
  R Pearlman et al, JAMA Oncology, December 15, 2016
• Universal Genetic Testing for Younger Patients With Colorectal Cancer
  E Vilar et al, JAMA Oncology, December 15, 2016
• Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next Generation Sequencing.
  Nowak Jonathan A et al. The Journal of molecular diagnostics : JMD 2016 Nov
• Towards value-based universal Lynch syndrome identification in endometrial cancer patients.
  Dottino Joseph A et al. Gynecologic oncology 2016 Dec 143(3) 451-452
• Ohio Statewide Colon Cancer Initiative 
• Time is running out to get a free cancer screening
  R Murray, Dayton Daily News, November 14, 2016
• Cost-effectiveness of routine screening for Lynch syndrome in endometrial cancer patients up to 70years of age.
  Goverde Anne et al. Gynecologic oncology 2016 Oct
• NICE recommends all bowel cancer patients to be tested for Lynch Syndrome
  Bowel Cancer UK, October 22, 2016
• NICE recommends wider use of tests to detect cancer-causing genetic condition
  NICE, United Kingdom, Draft Guidance, October 21, 2016
• Educational and Psychosocial Support Needs in Lynch Syndrome: Implementation and Assessment of an Educational Workshop and Support Group.
  Corines Marina J et al. Journal of genetic counseling 2016 Oct
• Implementing Public Health Genomics in Your State: Resources from the CDC Office of Public Health Genomics
  Disease: Lynch syndrome|Breast Cancer|Ovarian Cancer; Type: Education; State: Multiple States
• Exploring clinicians' attitudes about using aspirin for risk reduction in people with Lynch Syndrome with no personal diagnosis of colorectal cancer.
  Chen Yanni et al. Familial cancer 2016 Sep
• Genetic screening in young women diagnosed with endometrial cancer.
  Pecorino Basilio et al. Journal of gynecologic oncology 2016 Sep e4
• Facing my fear: did I have the cancer mutation that killed my dad? 
  JH Edelestein, The Guardian, September 9, 2016
• Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome.
  Watkins Jaclyn C et al. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2016 Aug

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Relevant Resources

• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB