OncDRS: An integrative clinical and genomic data platform for enabling translational research and precision medicine.

Orechia J1, Pathak A1, Shi Y1, Nawani A1, Belozerov A1, Fontes C1, Lakhiani C1, Jawale C1, Patel C1, Quinn D1, Botvinnik D1, Mei E1, Cotter E1, Byleckie J1,Ullman-Cullere M1, Chhetri P1, Chalasani P1, Karnam P1, Beaudoin R1, Sahu S1, Belozerova Y1, Mathew JP1.

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Abstract

We live in the genomic era of medicine, where a patient's genomic/molecular data is becoming increasingly important for disease diagnosis, identification of targeted therapy, and risk assessment for adverse reactions. However, decoding the genomic test results and integrating it with clinical data for retrospective studies and cohort identification for prospective clinical trials is still a challenging task. In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS) and a suite of tools called Oncology Data Retrieval Systems (OncDRS). OncDRS enables seamless data integration, secure and self-navigated query and extraction of clinical and genomic data from heterogeneous sources. Within a year of release, the system has facilitated more than 1500 research queries and has delivered data for more than 50 research studies.