miércoles, 30 de marzo de 2016

ATSDR - Toxicological Profile: Dinitrotoluenes

ATSDR - Toxicological Profile: Dinitrotoluenes



Release of Final Toxicological Profile for Dinitrotoluenes

Updated MRL list:

Toxicological Profile for Dinitrotoluenes



Toxicological Profile Information
The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The complete list of topics covered (chapter titles) is shown at the left and in more detail further down this page.
The focus of the profile is on health and toxicologic information. Therefore, each profile begins with a Public Health Statement that summarizes in nontechnical language, a substance's relevant properties.
A useful two page information sheet, the ToxFAQsTM, is also available.

Toxicological Profile Access
In order to access the ATSDR toxicological profiles' PDF files below, you must have Adobe Acrobat Reader.
You may download that program for free from this link to Adobe Exiting the ATSDR Web Site. and then use it to access (open) the files below that are labeled as PDF files.

Toxicological Profile PDF Complete Profile, 9.7 MB
The table of contents and list of individual PDF files are given below.

Preface PDF Preface, 715 KB
  • Disclaimer
  • Update statement
  • Foreword
  • Quick Reference for Health Care Providers
  • Contributors
  • Peer review
  • Contents
  • List of figures
  • List of tables


1.1 What is this substance?
1.2 What happens to it when it enters the environment? 
1.3 How might I be exposed to it? 
1.4 How can it enter and leave my body? 
1.5 How can it affect my health? 
1.6 How can it affect children? 
1.7 How can families reduce the risk of exposure? 
1.8 Is there a medical test to determine whether I have been exposed to it? 
1.9 What recommendations has the federal government made to protect human health? 
1.10 Where can I get more information?


Relevance to Public Health PDF 2. Relevance to Public Health, 499 KB
2.1 Background and environmental exposures in the United States 
2.2 Summary of health effects 
2.3 Minimal risk levels (MRLS)


Health Effects PDF 3. Health Effects, 8.2 MB
3.1 Introduction 
3.2 Discussion of health effects by route of exposure 
3.3 Genotoxicity 
3.4 Toxicokinetics 
3.5 Mechanisms of action 
3.6 Toxicities mediated through the neuroendocrine axis 
3.7 Children's susceptibility 
3.8 Biomarkers of exposure and effect 
3.9 Interactions with other chemicals 
3.10 Populations that are unusually susceptible 
3.11 Methods for reducing toxic effects 
3.12 Adequacy of the database


Chemical and Physical Information PDF 4. Chemical and Physical Information, 436 KB
4.1 Chemical identity 
4.2 Physical and chemical properties


Production, Import, Use, and Disposal PDF 5. Production, Import, Use, and Disposal, 463 KB
5.1 Production 
5.2 Import / Export 
5.3 Use 
5.4 Disposal


Potential for Human Exposure PDF 6. Potential for Human Exposure, 718 KB
6.1 Overview 
6.2 Releases to the environment 
6.3 Environmental fate 
6.4 Levels monitored or estimated in the environment 
6.5 General population and occupational exposure 
6.6 Exposures of children 
6.7 Populations with potentially high exposure 
6.8 Adequacy of the database


Analytical Methods PDF 7. Analytical Methods, 377 KB
7.1 Biological materials 
7.2 Environmental samples 
7.3 Adequacy of the database


Regulations, Advisories, and Guidelines PDF 8. Regulations, Advisories, and Guidelines, 390 KB

References PDF 9. References, 571 KB

Glossary PDF 10. Glossary, 412 KB

Appendices PDF Appendices, 766 KB
A. ATSDR minimal risk levels and worksheets 
B. Framework for ATSDR'S systematic review of health effects data for DNTs 
C. User's guide 
D. Acronyms, Abbreviations, and symbols,


Reference

Agency for Toxic Substances and Disease Registry (ATSDR). 2016. Toxicological profile for Dinitrotoluenes. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Disclaimer

All ATSDR toxicological profile PDF files are electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.

Where can I get more information?

If you have questions or concerns, please contact your community or state health or environmental quality department or:
For more information, contact: 
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30329-4027 
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Email: Contact CDC-INFO
ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.
Information line and technical assistance:
Phone: 888-422-8737 

To order toxicological profiles, contact:
National Technical Information Service
5285 Port Royal Road 
Springfield, VA 22161 
Phone: 800-553-6847 or 703-605-6000
Disclaimer 
Some PDF files may be electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.
The information contained here was correct at the time of publication. Please check with the appropriate agency for any changes to the regulations or guidelines cited.

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