Rev Clin Esp. 2019 Jan 25. pii: S0014-2565(18)30293-5. doi: 10.1016/j.rce.2018.09.017. [Epub ahead of print]
Spanish multidisciplinary clinical practice guidelines for Anderson-Fabry Disease in Adults. I. Method and recommendations.
[Article in English, Spanish]
Calderón Sandubete EJ1, Briones Pérez de la Blanca E2, Alonso-Ortiz Del Río C3, Santamaría Olmo R4, López Mendoza M5, Barcos Martínez M6, Márquez Infante C7, Marín-León I8; en nombre del Grupo Guía Fabry.
Anderson-Fabry disease is a severe progressive multisystem condition of genetic origin that affects men and women, reducing their life expectancy and quality of life. The considerable variability in its clinical expression, the difficulties in diagnosing the condition and the current availability of several alternatives for its treatment represent a considerable challenge that justifies the development of evidence-based clinical practice guidelines that can help health professionals in the decision-making process for managing these patients. To develop these guidelines, we conducted a systematic search of the main reference databases using strategies adapted to each of the 32 clinical questions considered. We prepared documents to synthesise the evidence and assess its quality for each of the questions. The methodology employed is based on the Spanish methodology manual for preparing clinical practice guidelines, incorporating the GRADE methodology in the assessment of the scientific evidence and the preparation of the recommendations, considering the quality of the evidence, the risk-benefit balance, patient values and preferences, equity and use of resources. For the definitive preparation of the recommendations, we conducted a structured consensus process based on the Delphi-RAND methodology in 2 rounds, with an expert panel proposed by various scientific societies, research centres and patient associations. Ultimately, we developed 92 specific recommendations for managing Fabry disease.
Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.
Basada en evidencia; Clinical guidelines; Cribado; Diagnosis; Diagnóstico; Evidence-based; Fabry; Fabry disease; Guía clínica; Screening; Tratamiento; Treatment