Analysis of CD8+ T cell response during the 2013–2016 Ebola epidemic in West Africa | PNAS

Analysis of CD8+ T cell response during the 2013–2016 Ebola epidemic in West Africa | PNAS

Monday, July 23, 2018

Insights from Ebola Survivors’ Immune Cells Inform Vaccine Design

NIAID-Supported Study First to Characterize T-Cell Responses in Large Sierra Leone Cohort

Specific memory T cells from people who survived the 2013-2016 Ebola outbreak in Sierra Leone were more likely to respond to a viral protein on the inside of the virus, report NIAID-supported researchers in a paper out today in PNAS. This cell-based immunity leads to destruction of virus-infected cells and may be important for Ebola vaccine design.

Analysis of CD8+ T cell response during the 2013–2016 Ebola epidemic in West Africa

Saori Sakabe, Brian M. Sullivan, Jessica N. Hartnett, Refugio Robles-Sikisaka, Karthik Gangavarapu, Beatrice Cubitt, Brian C. Ware, Dylan Kotliar, Luis M. Branco, Augustine Goba, Mambu Momoh, John Demby Sandi, Lansana Kanneh, Donald S. Grant, Robert F. Garry, Kristian G. Andersen, Juan Carlos de la Torre, Pardis C. Sabeti, John S. Schieffelin, and Michael B. A. Oldstone

PNAS July 23, 2018. 201806200; published ahead of print July 23, 2018. https://doi.org/10.1073/pnas.1806200115

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1. Contributed by Michael B. A. Oldstone, June 18, 2018 (sent for review April 13, 2018; reviewed by Arturo Casadevall and Bruce D. Walker)