Clinical Trials Monitor
Section edited by Leisha A. Emens, MD, PhD
Reports on important new trial results; updates on new drug approvals and ongoing clinical studies; key perspectives on clinical issues and advances in the field relevant to the everyday use of cancer immunotherapy in the clinic. This section also aims to address trial design and analysis considerations that may be unique to cancer immunotherapy, and to provide guidance for implementing and managing the use of cancer immunotherapies in the clinic.
- CLINICAL TRIALS MONITOR
Current clinical trials testing the combination of immunotherapy with radiotherapy
Increasing evidence demonstrates that radiation acts as an immune stimulus, recruiting immune mediators that enable anti-tumor responses within and outside the radiation field. There has been a rapid expansion...Journal for ImmunoTherapy of Cancer 2016 4:51Published on: 20 September 2016 - CLINICAL TRIALS MONITOR
Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy
With the recent regulatory approval of Talimogene laherparepvec (T-VEC) for the treatment of advanced of melanoma in the United States, Europe and Australia, oncolytic virus immunotherapy has earned its place ...Journal for ImmunoTherapy of Cancer 2016 4:53Published on: 20 September 2016 - CLINICAL TRIALS MONITOR
PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?
Research in cancer immunology is currently accelerating following a series of cancer immunotherapy breakthroughs during the last 5 years. Various monoclonal antibodies which block the interaction between check...Journal for ImmunoTherapy of Cancer 2016 4:48Published on: 16 August 2016 - CLINICAL TRIALS MONITOR
Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine
Because the benefits of immune checkpoint blockade may be restricted to tumors with pre-existing immune recognition, novel therapies that facilitate de novo immune activation are needed. DRibbles is a novel multi...Journal for ImmunoTherapy of Cancer 2016 4:25Published on: 17 May 2016 - EDITORIALJournal for ImmunoTherapy of Cancer 2015 3:49Published on: 20 October 2015
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