Lobular Breast Cancer
This special series takes a translational view of lobular breast cancer, from bedside to bench and back. The second most common breast cancer subtype, lobular breast cancer displays many unique molecular and clinical properties. Leaders in the field explore the molecular biology, pathology, risk factors, imaging, treatment and prognosis of this breast cancer.
Prof. Ulrich Lehmann. Hannover Medical School
- EDITORIAL
Lobular breast cancer - the most common special subtype or a most special common subtype?
Lobular breast cancer is not only the second most common breast cancer subtype, known for decades, but also a tumour entity that still poses many unresolved questions. These include questions about the targets...Breast Cancer Research 2015 17:99Published on: 28 July 2015 - REVIEW
Lobular breast cancer series: imaging
The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors. However...Breast Cancer Research 2015 17:94Published on: 11 July 2015 - REVIEW
Molecular drivers of lobular carcinoma in situ
Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesi...Breast Cancer Research 2015 17:76Published on: 4 June 2015 - REVIEW
Lobular breast cancer: incidence and genetic and non-genetic risk factors
While most invasive breast cancers consist of carcinomas of the ductal type, about 10% are invasive lobular carcinomas. Invasive lobular and ductal carcinomas differ with respect to risk factors. Invasive lobu...Breast Cancer Research 2015 17:37Published on: 13 March 2015 - REVIEW
Lobular breast cancer: molecular basis, mouse and cellular models
Infiltrating lobular breast cancer (ILC) is the most common special breast cancer subtype. With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being confined almost exclusiv...Breast Cancer Research 2015 17:16Published on: 8 February 2015 - REVIEW
Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics
Invasive lobular carcinoma of the breast is the most common ‘special’ morphological subtype of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good prognostic phenotype, being low ...Breast Cancer Research 2015 17:12Published on: 30 January 2015
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