www.umd.be/BRCA1/

www.umd.be/BRCA1/

BRCA Share was launched on April 21st 2015 BRCA Share is a novel gene datashare initiative that provides scientists and commercial laboratory organizations around the world with open access to BRCA1 and BRCA2 genetic data. The program’s goal is to accelerate research on BRCA gene mutations, particularly variants of uncertain significance, to improve the ability of clinical laboratory diagnostics to predict which individuals are at risk of developing these cancers. BRCA Share is an open user group co-founded by Inserm and Quest Diagnostics. Other participants include Laboratory Corporation of America (LabCorp) and the French UNICANCER Genetic Group (UGG), composed of sixteen academic laboratories performing BRCA1 and BRCA2 testing in France. BRCA Share builds on Inserm and UGG’s established BRCA gene data curation process as well as existing BRCA data in the Universal Mutation Database (UMD-BRCA1/2) generated by the UGG member entities. BRCA Share provides several features unique to a gene datashare program. BRCA Share is a public-private initiative through which commercial entities will fund the user group on a sliding scale to encourage participation from labs of all sizes; Research entities and individuals with a research-only focus on BRCA can participate at no charge. Other benefits include the immediate advantage of an established data curation and VUS interpretation system and investment by commercial entities in functional studies to determine VUS pathogenicity. Joining BRCA Share As of June 1st 2015, registration will be required to access the UMD databases of BRCA1 and BRCA2 gene data. BRCA Share is structured as a user group. Any participant in BRCA Share is expected to timely share their BRCA1 and 2 gene variant data with other users and abide by other customary obligations. How to Join BRCA Share? • Non-commercial individual investigators and academic research organizations: º Quickly access the BRCA Share data by agreeing to the program’s user group agreement • Commercial entities: º Join BRCA Share through a sublicense agreement with Quest Diagnostics.   To form this agreement, please email BRCAShare@QuestDiagnostics.com For any other questions, please email BRCAShare@QuestDiagnostics.com For more information about BRCA Share, read the announcement

The databases of BRCA1 and BRCA2 mutations were built using the "Universal Mutation Database" tool.