lunes, 26 de septiembre de 2016

Drug Shows Promise Against MS in Mouse Study: MedlinePlus Health News

Drug Shows Promise Against MS in Mouse Study: MedlinePlus Health News

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Drug Shows Promise Against MS in Mouse Study

Laquinimod seemed to slow progression of the neurological disorder, but human trials needed
By Mary Elizabeth Dallas
Wednesday, September 21, 2016
WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- An experimental drug, laquinimod, appears to prevent or slow the progression of multiple sclerosis (MS) in mice, according to a new study.
"This study has given us more insight into how laquinimod works," said study author Dr. Scott Zamvil, of the University of California, San Francisco. "But because this was an animal study, more research needs to be done before we know if it could have similar results in people."
Still, "these results are promising because they provide hope for people with progressive MS, an advanced version of the disease for which there is currently no treatment," Zamvil said in a news release from the American Academy of Neurology.
A healthy immune system has T cells and B cells that help the body prevent infections. However, for people with MS, these cells create antibodies that attack and destroy the protective outer coating (myelin) that surrounds nerves in the brain and spinal cord.
In the new study, Zamvil's team used 50 mice bred to develop a spontaneous form of MS. The mice received either a daily dose of oral laquinimod, or a placebo (water). The investigators then analyzed and counted the rodents' T cells and B cells.
Only 29 percent of the mice taking laquinimod developed MS compared to 58 percent of those given the placebo, the study found.
The researchers believe that the drug may help prevent MS, since there was a 96 percent reduction in harmful clusters of B cells -- which are only found in people with MS.
In a second experiment that involved 22 mice, Zamvil's group gave the animals laquinimod after they had experienced some MS-linked paralysis. The disease progression among the mice slowed significantly as a result, the findings showed.
Dr. Paul Wright is chair of neurology at North Shore University Hospital in Manhasset, N.Y. He reviewed the new findings and agreed that laquinimod "may provide a neuroprotective effect."
Wright said that "this is a very promising study and provides us with insight into a novel medication that may have benefit for patients with this devastating disease." However, the research was "performed in mice, and human studies need to be performed to confirm the effects and ensure human tolerability of the medication," he added.
The study was published online Sept. 21 in the journal Neurology, Neuroimmunology & Neuroinflammation.
SOURCES: Paul Wright, M.D., chair, neurology, North Shore University Hospital, Manhasset, and Long Island Jewish Medical Center, New Hyde Park, N.Y.; American Academy of Neurology, news release, Sept. 21, 2016
News stories are provided by HealthDay and do not reflect the views of MedlinePlus, the National Library of Medicine, the National Institutes of Health, the U.S. Department of Health and Human Services, or federal policy.
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