NCI Visuals Online: Image Details
Developing Novel Vaccine Delivery Systems for Cancer Therapy
07/25/2016 01:00 PM EDT
Researchers at the Texas Center for Cancer Nanomedicine (TCCN) are working on the devlopment of nano-vaccines for cancer therapy. In this research, bone marrow cells were stimulated with cytokines (signaling molecules used extensively in intercellular communication) to favor differentiation into antigen presenting cells, known as dendritic cells. These dendritic cells are then presented with the nano-vaccines (as shown in this image), which are porous silicon particle discs loaded with immune stimulating molecules and tumor antigens. These now activated cells are then injected back into the host to stimulate an anti-tumor response.