domingo, 31 de julio de 2016

The Cancer Epidemiology Descriptive Cohort Database: A Tool to Support Population-Based Interdisciplinary Research. - PubMed - NCBI

The Cancer Epidemiology Descriptive Cohort Database: A Tool to Support Population-Based Interdisciplinary Research. - PubMed - NCBI

 2016 Jul 20. pii: cebp.0412.2016. [Epub ahead of print]

The Cancer Epidemiology Descriptive Cohort Database: A Tool to Support Population-Based Interdisciplinary Research.



We report on the establishment of a web-based Cancer Epidemiology Descriptive Cohort Database (CEDCD). The CEDCD's goals are to: enhance awareness of resources, facilitate interdisciplinary research collaborations, and support existing cohorts for the study of cancer-related outcomes.


Comprehensive descriptive data were collected from large cohorts established to study cancer as primary outcome, using a newly developed questionnaire. These included an inventory of baseline and follow-up data, biospecimens, genomics, policies and protocols. Additional descriptive data extracted from publicly available sources were also collected. This information was entered in a querable and publicly accessible database. We summarized the descriptive data across cohorts and reported the characteristics of this resource.


As of December 2015, the CEDCD includes data from 46 cohorts representing more than 6.5 million individuals (29% ethnic/racial minorities). Overall, 78% of the cohorts have collected blood at least once, 57% at multiple time points, and 46% collected tissue samples. Genotyping has been performed by 67% of the cohorts, while 46% have performed whole genome or exome sequencing in subsets of enrolled individuals. Information on medical conditions other than cancer have been collected in over 50% of the cohorts. More than 600,000 incident cancer cases and over 40,000 prevalent cases are reported, with 24 cancer sites represented.


The CEDCD assembles detailed descriptive information on a large number of cancer cohorts in a searchable database.


Information from the CEDCD may assist the interdisciplinary research community by facilitating identification of well-established population resources and large-scale collaborative and integrative research.
Copyright ©2016, American Association for Cancer Research.

[PubMed - as supplied by publisher]

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