Unique Presentation of Orf Virus Infection in a Thermal Burn Patient After Receiving an Autologous Skin Graft.

Hsu CH1, Rokni GR2, Aghazadeh N3, Brinster N4, Li Y5, Muehlenbachs A6, Goldsmith CS6, Zhao H5, Petersen B5, McCollum AM5, Reynolds MG5.

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Abstract

We present a report of a burn patient who developed skin lesions on her skin-graft harvest and skin-graft recipient (burn) sites. Orf virus infection was confirmed by a combination of diagnostic assays, including molecular tests, immunohistochemistry, pathology and electron microscopy. DNA sequence analysis grouped this orf virus isolate among isolates from India. Though no definitive source of infection was determined from this case, this is the first reported case of orf virus infection in a skin graft harvest. Skin graft patients with exposures to animals may be at risk for this viral infection.

Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.