Genetic variants in Alzheimer disease - molecular and brain network approaches and MORE

Public Health Genomics Knowledge Base (v1.0)

June 30 - July 7, 2016 

ALZHEIMER’S DISEASE

Last Updated: Jun 30, 2016

• Genetic variants in Alzheimer disease - molecular and brain network approaches.
  Gaiteri Chris et al. Nature reviews. Neurology 2016 Jun
• Lack of association between genetic polymorphism of circadian genes (PER2, PER3, CLOCK and OX2R) with late onset depression and Alzheimer's disease in a sample of a Brazilian population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).
  Pereira Patricia Araújo, et al. Current Alzheimer research 2016 6
• Non-Ceruloplasmin Copper Appears a Disctinct Subtype of Alzheimer`s Disease: A Study of EEG-Derived Brain Activity.
  Tecchio Franca, et al. Current Alzheimer research 2016 6
• What is Alzheimer’s Disease? 
• Genetic Variants of the FADS Gene Cluster Are Associated with Erythrocyte Membrane LC PUFA Levels in Patients with Mild Cognitive Impairment.
  Schuchardt J P, et al. The journal of nutrition, health & aging 2016 0 (6) 611-20
• Polymorphisms of CHAT but not TFAM or VR22 are Associated with Alzheimer Disease Risk.
  Gao Lili, et al. Medical science monitor : international medical journal of experimental and clinical research 2016 0 1924-35
• Personal utility in genomic testing: is there such a thing?
  Bunnik Eline M et al. Journal of medical ethics 2015 Apr 41(4) 322-6
• Determinants of iron accumulation in the normal aging brain.
  Pirpamer Lukas, et al. Neurobiology of aging 2016 7 149-55
• ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.
  Cukier Holly N, et al. Neurology. Genetics 2016 6 (3) e79
• Diffusion Tensor Changes According to Age at Onset and Apolipoprotein E Genotype in Alzheimer Disease.
  Kim Min-Jeong, et al. Alzheimer disease and associated disorders 2016 5
• Genome-wide association study identifies 74 loci associated with educational attainment.
  Okbay Aysu, et al. Nature 2016 5 (7604) 539-42
• Synergistic Increase of Serum BDNF in Alzheimer Patients Treated with Cerebrolysin and Donepezil: Association with Cognitive Improvement in ApoE4 Cases.
  Alvarez X Anton, et al. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2016 4
• Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort.
  Habes M, et al. AJNR. American journal of neuroradiology 2016 5
• Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.
  Voevodskaya Olga, et al. Neurology 2016 5 (19) 1754-61
• Genome-wide association study of serum coenzyme Q10 levels identifies susceptibility loci linked to neuronal diseases.
  Degenhardt Frauke, et al. Human molecular genetics 2016 5

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Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB