miércoles, 29 de diciembre de 2010
Contact Dermatitis. 2011 Jan;64(1):2-23. doi: 10.1111/j.1600-0536.2010.01800.x.
Genetic factors in contact allergy-review and future goals.
Schnuch A, Westphal G, Mössner R, Uter W, Reich K.
Information Network of Departments of Dermatology (IVDK) at the University of Göttingen, D 37075 Göttingen, Germany Institute of Prevention and Occupational Medicine (IPA), D 44789 Bochum, Germany Department of Dermatology, University of Göttingen, D 37075 Göttingen, Germany Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-Nuremberg, D 91054 Erlangen, Germany Dermatologicum, D 20354 Hamburg, Germany.
The genetics of contact allergy are still only partly understood, despite decades of research; this might be a consequence of inadequately defined phenotypes used in the past. A recommendation is to study an extreme phenotype, namely, polysensitization (sensitization to three or more unrelated allergens). Another approach to unravel the genetics of contact allergy is the study of candidate genes. In this review, we summarize studies on the associations between genetic variation (e.g. single-nucleotide polymorphisms) in certain candidate genes and contact allergy. Polymorphisms and mutations affecting the following proteins were studied: (i) filaggrin; (ii) N-acetyltransferase (NAT) 1 and 2; (iii) glutathione-S-transferase (GST) M and T; (iv) manganese superoxide dismutase; (v) angiotensin-converting enzyme (ACE); (vi) tumour necrosis factor (TNF); and (vii) interleukin-16 (IL-16). The polymorphisms of NAT1, NAT2, GSTM, GSTT, ACE, TNF and IL-16 were shown to be associated with an increased risk of contact allergy. In one of our studies, the increased risk conferred by the TNF and IL-16 polymorphisms was confined to polysensitized individuals. Other relevant candidate genes may be identified by studying diseases related to contact allergy in terms of clinical symptoms, a more general pathology (inflammation), and possibly an overlapping genetic background, such as irritant contact dermatitis.
© 2010 John Wiley & Sons A/S.
PMID: 21166814 [PubMed - in process]
Genetic factors in contact allergy-review and futu... [Contact Dermatitis. 2011] - PubMed result