miércoles, 29 de diciembre de 2010
Immun Ageing. 2010 Dec 14;7(1):16. [Epub ahead of print]
Alzheimer's disease gene signature says: beware of brain viral infections.
Porcellini E, Carbone I, Ianni M, Licastro F.
BACKGROUND: Recent findings from a genome wide association investigation in a large cohort of patients with Alzheimer's disease (AD) and non demented controls (CTR) showed that a limited set of genes was in a strong association (p > l0-5 ) with the disease.
PRESENTATION OF THE HYPOTHESIS: In this report we suggest that the polymorphism association in 8 of these genes is consistent with a non conventional interpretation of AD etiology. Nectin-2 (NC-2), apolipoprotein E (APOE), glycoprotein carcinoembryonic antigen related cell adhesion molecule- 16 (CEACAM-16), B-cell lymphoma-3 (Bcl-3), translocase of outer mitochondrial membrane 40 homolog (T0MM-40), complement receptor-1 (CR-l), APOJ or clusterin and C-type lectin domain A family-16 member (CLEC-16A) result in a genetic signature that might affect individual brain susceptibility to infection by herpes virus family during aging, leading to neuronal loss, inflammation and amyloid deposition.
IMPLICATIONS OF THE HYPOTHESIS: We hypothesized that such genetic trait may predispose to AD via complex and diverse mechanisms each contributing to an increase of individual susceptibility to brain viral infections.
PMID: 21156047 [PubMed - as supplied by publisher]
Alzheimer's disease gene signature says: beware of... [Immun Ageing. 2010] - PubMed result