viernes, 31 de diciembre de 2010

Characteristics of Patients with Oseltamivir-Resistant Pandemic (H1N1) 2009, United States [EID] DOI: 10.3201/eid1702.101724

DOI: 10.3201/eid1702.101724
Suggested citation for this article: Graitcer SB, Gubareva L, Kamimoto L, Doshi S, Vandermeer M, Louie J, et al. Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States. Emerg Infect Dis. 2011 Feb; [Epub ahead of print]

Characteristics of Patients with Oseltamivir-Resistant Pandemic (H1N1) 2009, United States
Samuel B. Graitcer, Larisa Gubareva, Laurie Kamimoto, Saumil Doshi, Meredith Vandermeer, Janice Louie, Christine Waters, Zack Moore, Katrina Sleeman, Margaret Okomo-Adhiambo, Steven A. Marshall, Kirsten St. George, Chao-Yang Pan, Jennifer M. LaPlante, Alexander Klimov, and Alicia M. Fry

Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.B. Gratcer, L. Gubareva, L. Kamimoto, S. Doshi, K. Sleeman, M. Okomo-Adhiambo, A. Klimov, A.M. Fry); Oregon Department of Human Services, Portland, Oregon, USA (M. Vandermeer); California Department of Health, Sacramento, California, USA (J. Louie, C.-Y. Pan); New York State Department of Health, Albany, New York, USA (C. Waters, K. St. George, J.M. LaPlante); North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA (Z. Moore); and Wisconsin Department of Health, Madison, Wisconsin, USA (S.A. Marshall)

During April 2009–June 2010, thirty-seven (0.5%) of 6,740 pandemic (H1N1) 2009 viruses submitted to US surveillance systems were oseltamivir resistant. Most patients with oseltamivir-resistant infections were severely immunocompromised (76%) and had received oseltamivir before specimen collection (89%). No evidence was found for community circulation of resistant viruses; only 4 (unlinked) patients had no oseltamivir exposure.

During April, 2009–June, 2010 the United States had enhanced surveillance for oseltamivir resistance among pandemic influenza A (H1N1) 2009 viruses. We describe characteristics of patients infected with oseltamivir-resistant and oseltamivir-susceptible pandemic (H1N1) 2009 virus.


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