Why stem cell-like T cells are shaping the next generation of CAR-T therapies A rare immune cell subset with the capacity to self-renew, persist long-term, and drive potent antitumor responses Written byAndrea Corona

https://www.drugdiscoverynews.com/why-stem-cell-like-t-cells-are-shaping-the-next-generation-of-car-t-therapies-17245 CAR-T cell therapy has transformed outcomes in certain blood cancers, but it has always carried the fundamental vulnerability that the cells that make it work do not always last. Infused T cells can expand, contract, and exhaust, in turn leaving patients who initially responded without the sustained immune pressure needed to prevent relapse. Understanding why some patients maintain durable remissions while others do not has pointed the field toward a rare immune cell subset that may hold the answer.