Polymorphisms in FCGR3A and Degree of Trastuzumab Benefit | Breast Cancer | JAMA Oncology | The JAMA Network

Polymorphisms in FCGR3A and Degree of Trastuzumab Benefit | Breast Cancer | JAMA Oncology | The JAMA Network

November 03, 2016

Association of Polymorphisms in FCGR2A and FCGR3A With Degree of Trastuzumab Benefit in the Adjuvant Treatment of ERBB2/HER2–Positive Breast CancerAnalysis of the NSABP B-31 Trial

Patrick G. Gavin, BS¹; Nan Song, PhD¹; S. Rim Kim, MD¹; et alCorey Lipchik, BS¹; Nicole L. Johnson, BS¹; Hanna Bandos, PhD²; Melanie Finnigan, BS¹; Priya Rastogi, MD^1,3; Louis Fehrenbacher, MD^1,4; Eleftherios P. Mamounas, MD^1,5; Sandra M. Swain, MD^1,6,7; D. Lawrence Wickerham, MD^1,8; Charles E. Geyer Jr, MD^1,9; Jong-Hyeon Jeong, PhD^1,2; Joseph P. Costantino, Dr PH^1,2; Norman Wolmark, MD^1,8; Soonmyung Paik, MD^1,10; Kay L. Pogue-Geile, PhD¹

Author Affiliations

JAMA Oncol. Published online November 3, 2016. doi:10.1001/jamaoncol.2016.4884

Public Health Genomics Knowledge Base (v1.2)

Last Posted: Nov-04-2016 2PM

 Breast Cancer expanded expanded

Association of Polymorphisms in FCGR2A and FCGR3A With Degree of Trastuzumab Benefit in the Adjuvant Treatment of ERBB2/HER2–Positive Breast Cancer
PG Gavin et al, JAMA Oncology, November 3, 2016

Predictive Value of FcR Polymorphisms A Further Step on the Long and Winding Road to Application
R Dolcetti, JAMA Oncology, November 3, 2016

Advocacy group anecdotes present one-sided picture of genetic testing for breast cancer
MC Jaklevic, Health News Reviews, October 2016

More information on this topic

Last Updated: Nov 04, 2016

• Association of Polymorphisms in FCGR2A and FCGR3A With Degree of Trastuzumab Benefit in the Adjuvant Treatment of ERBB2/HER2–Positive Breast Cancer
  PG Gavin et al, JAMA Oncology, November 3, 2016
• Predictive Value of FcR Polymorphisms A Further Step on the Long and Winding Road to Application
  R Dolcetti, JAMA Oncology, November 3, 2016
• Advocacy group anecdotes present one-sided picture of genetic testing for breast cancer
  MC Jaklevic, Health News Reviews, October 2016
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  Disease: Breast Cancer|Ovarian Cancer; Type: Data|Program; State: Georgia
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  Disease: Ovarian Cancer|Breast Cancer; Type: Data|Program; State: Georgia
• Inherited chromosomally-integrated human herpesvirus 6 and breast cancer.
  Gravel Annie, et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 10
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Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB