Advanced Molecular Detection Clips Content

Public Health Genomics Knowledge Base (v1.2)

Advanced Molecular Detection Clips

About Advanced Molecular Detection Clips

Clips are selected weekly from a variety of sources, including PubMed, journal tables of contents, and online media. Special emphasis is given to the use of next-generation genetic sequencing in infectious disease public health surveillance, investigation, and development of new diagnostics and interventions. The collection is not comprehensive but aims to capture highlights, while surveying a wide range of topics. CDC-authored articles are flagged. Items marked I&E address aspects of implementation or evaluation in clinical or public health practice.

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Advanced Molecular Detection Clips Content

• News
• Policy
• Concepts / Comments
• Methods / Tools
• Evolution / Ecology / Populations
• Pathogenicity / Antimicrobial Resistance
• Detection / Diagnosis
• Epidemiology / Outbreaks / Transmission
• Antimicrobials / Vaccines / Interventions
• Host-Microbe Interactions

NEWS

• European diseases left a genetic mark on Native Americans
  Price M. Science, Nov 15, 2016.
• Researchers develop USB stick that tests for HIV
  Healio, Nov 10, 2016.
• Mosquitos Can Infect Humans with Zika and Chikungunya in One Bite
  Henry BA. The Scientist, Nov 15, 2016.
• Zika Infection in U.S. Is Still Rare So Far, Blood Donations Indicate
  Saint Louis C. New York Times, Nov 15, 2016.

POLICY

• Use of transgenic Aedes aegypti in Brazil: risk perception and assessment.
  Paes de Andrade Paulo et al. Bulletin of the World Health Organization 2016 Oct (10) 766-771

CONCEPTS / COMMENTS

• A laboratory in your pocket.
  Radin Jennifer M et al. Lancet (London, England) 2016 Oct (10054) 1875
• Big Data for Infectious Disease Surveillance and Modeling
  Bansal S, et al. J Infect Dis 2016; 214(suppl 4):S375-S379.
• First flu is forever
  Viboud C, Epstein SL. Science, Nov 11, 2016.
• Species Mash-up.
  Argimón Silvia et al. Nature reviews. Microbiology 2016 Nov (12) 730

METHODS / TOOLS

• Microbial genome-wide association studies: lessons from human GWAS.
  Power Robert A et al. Nature reviews. Genetics 2016 Nov
• The Molecular Blueprint of a Fungus by Next-Generation Sequencing (NGS).
  Grumaz Christian et al. Methods in molecular biology (Clifton, N.J.) 2017 361-383
• Identifying transmission clusters with Cluster Picker and HIV-TRACE.
  Rose Rebecca et al. AIDS research and human retroviruses 2016 Nov
• Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification.
  Wagner Josef et al. BMC microbiology 2016 Nov (1) 274

EVOLUTION / ECOLOGY / POPULATIONS

• Host associations and genomic diversity of Borrelia hermsii in an endemic focus of tick-borne relapsing fever in western North America.
  Johnson Tammi L et al. Parasites & vectors 2016 Nov (1) 575 
• Capsular Switching and Other Large-Scale Recombination Events in Invasive Sequence Type 1 Group B Streptococcus.
  Neemuchwala Alefiya et al. Emerging infectious diseases 2016 Nov (11) 1941-1944
• Origins of the current seventh cholera pandemic
  Hu D, et al. Proc Natl Acad Sci, Nov 2016.
• Molecular evidence of the close relatedness of clinical, gull and wastewater isolates of quinolone-resistant Escherichia coli.
  Varela Ana Rita et al. Journal of global antimicrobial resistance 2015 Dec (4) 286-289
• Red squirrels in the British Isles are infected with leprosy bacilli.
  Avanzi Charlotte et al. Science (New York, N.Y.) 2016 Nov (6313) 744-747
• Emergence of human G2P[4] rotaviruses containing animal derived gene segments in the post-vaccine era.
  Matthijnssens Jelle et al. Scientific reports 2016 Nov 36841
• Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station.
  Knox Benjamin P et al. mSphere (5)
• Comparative Bioinformatics Analysis of Transcription Factor Genes Indicates Conservation of Key Regulatory Domains among Babesia bovis, Babesia microti, and Theileria equi.
  Alzan Heba F et al. PLoS neglected tropical diseases 2016 Nov (11) e0004983

PATHOGENICITY / ANTIMICROBIAL RESISTANCE

• Staphylococcal chromosomal cassettes mec (SCCmec): A mobile genetic element in methicillin-resistant Staphylococcus aureus.
  Liu Junyan et al. Microbial pathogenesis 2016 Nov 56-67
• Comparative Genome Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Sequence Type 131 Strains from Nepal and Japan.
  Miyoshi-Akiyama Tohru et al. mSphere (5)
• Serotype IV Sequence Type 468 Group B Streptococcus Neonatal Invasive Disease, Minnesota, USA.
  Teatero Sarah et al. Emerging infectious diseases 2016 Nov (11) 1937-1940
• Identification of a novel mutation at the primary dimer interface of GyrA conferring fluoroquinolone resistance in Clostridium difficile.
  Mac Aogáin Micheál et al. Journal of global antimicrobial resistance 2015 Dec (4) 295-299
• The spread and clinical impact of ST14CC-PBP3 type IIb/A, a clonal group of non-typeable Haemophilus influenzae with chromosomally mediated beta-lactam resistance - a prospective observational study.
  Månsson Viktor et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2016 Nov
• Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
  Bryant Josephine M et al. Science (New York, N.Y.) 2016 Nov (6313) 751-757
• Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.
  Kossyvakis A et al. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2016 Nov
• Viral factors in influenza pandemic risk assessment.
  Lipsitch Marc et al. eLife 2016 Nov 
• Systemic Approach to Virulence Gene Network Analysis for Gaining New Insight into Cryptococcal Virulence.
  Malachowski Antoni N et al. Frontiers in microbiology 2016 1652

DETECTION / DIAGNOSIS

• Routine identification of Nocardia species by MALDI-TOF mass spectrometry.
  Girard Victoria et al. Diagnostic microbiology and infectious disease 2016 Oct
• The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis.
  Timbrook Tristan T et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Sep 
• Impact of rapid diagnostic testing for chlamydia and gonorrhea on appropriate antimicrobial utilization in the emergency department.
  Rivard Kaitlyn R et al. Diagnostic microbiology and infectious disease 2016 Oct 
• Development and evaluation of a multiplex real-time PCR for the detection of IMP, VIM, and OXA-23 carbapenemase gene families on the BD MAX open system.
  Teo Jeanette W P et al. Diagnostic microbiology and infectious disease 2016 Dec (4) 358-361
• Bacterial Load in Daily Urine Samples of Patients Infected with Mycoplasma genitalium, Mutation Analysis, and Response to Treatment.
  Gossé M et al. Infectious diseases in obstetrics and gynecology 2016 8382469
• Novel pH sensing semiconductor for point-of-care detection of HIV-1 viremia.
  Gurrala R et al. Scientific reports 2016 Nov 36000
• Molecular Detection of Resistance to Azole Components.
  Posteraro Brunella et al. Methods in molecular biology (Clifton, N.J.) 2017 423-435
• Molecular Detection of Resistance to Echinocandins.
  Posteraro Brunella et al. Methods in molecular biology (Clifton, N.J.) 2017 413-421
• Identification of cryptic Candida species by MALDI-TOF mass spectrometry, not all MALDI-TOF systems are the same: focus on the C. parapsilosis species complex.
  Haas Marion et al. Diagnostic microbiology and infectious disease 2016 Dec (4) 385-386
• Transcriptional categorization of the etiology of pneumonia syndrome in pediatric patients in malaria endemic areas.
  Silterra Jacob et al. The Journal of infectious diseases 2016 Nov

EPIDEMIOLOGY / OUTBREAKS / TRANSMISSION

• ESBL-Producing and Macrolide-Resistant Shigella sonnei Infections among Men Who Have Sex with Men, England, 2015.
  Mook Piers et al. Emerging infectious diseases 2016 Nov (11) 1948-1952
• Mycobacterium chimaera Outbreak Associated With Heater-Cooler Devices: Piecing the Puzzle Together.
  Sommerstein Rami et al. Infection control and hospital epidemiology 2016 Nov 1-6
• Concurrency and HIV transmission network characteristics among MSM with recent HIV infection.
  Pines Heather A et al. AIDS (London, England) 2016 Nov (18) 2875-2883

ANTIMICROBIALS / VACCINES / INTERVENTIONS

• Occult HBV Infection in Immunized Neonates Born to HBsAg-Positive Mothers: A Prospective and Follow-Up Study.
  Lu Ying et al. PloS one 2016 (11) e0166317

HOST-MICROBE INTERACTIONS

• Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study.
  Lankelma Jacqueline M et al. Intensive care medicine 2016 Nov
• The Human Microbiome before Birth.
  Blaser Martin J et al. Cell host & microbe 2016 Nov (5) 558-560
• Lifestyle chemistries from phones for individual profiling
  Bouslim ani A. Proc Natl Acad Sci, Nov 2016.
• Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis.
  Petruccioli Elisa et al. The European respiratory journal 2016 Nov
• Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting.
  Gostic Katelyn M et al. Science (New York, N.Y.) 2016 Nov (6313) 722-726

Note:  indicates that at least one CDC-affiliated author;  indicates that the article addresses aspects of implementation or evaluation in clinical or public health practice.

Disclaimer: Articles listed in the Advanced Molecular Detection Clips are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the clips does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.