domingo, 7 de agosto de 2016

Outcome of thyroid gene expression classifier testing in clinical practice. - PubMed - NCBI

Outcome of thyroid gene expression classifier testing in clinical practice. - PubMed - NCBI

 2016 Feb;126(2):524-7. doi: 10.1002/lary.25607. Epub 2015 Sep 7.

Outcome of thyroid gene expression classifier testing in clinical practice.

Abstract

OBJECTIVES/HYPOTHESIS:

Gene expression classifiers can safely reduce diagnostic thyroid surgery for fine-needle aspiration cytology (FNAC) indeterminate thyroid nodules.

STUDY DESIGN:

Retrospective review, single-institution, single-practice surgeon.

METHODS:

Three-year retrospective review of indeterminate FNAC that went on to gene expression classifier testing.

RESULTS:

A total of 520 patients met American Thyroid Association guideline criteria for surgeon-performed ultrasound-guided FNAC for a thyroid nodule with on-site cytopathology. The indeterminate (Bethesda III or IV) FNAC rate was 9%. Prevalence of malignancy in FNAC indeterminate was 21%. Thirty-two cases went on to gene expression classifier testing. Fourteen were benign, 15 suspicious, and three with no result.

CONCLUSIONS:

Benign gene expression classifier testing had an estimated negative predictive value of 100% during the study period. These patients have been observed for a mean and median duration of 14 and 7 months, respectively. In this small series, 14 of 29 patients with indeterminate FNAC were spared diagnostic surgery.

LEVEL OF EVIDENCE:

4.
© 2015 The American Laryngological, Rhinological and Otological Society, Inc.

KEYWORDS:

Thyroid; fine needle aspiration cytology; gene expression testing

PMID:
 
26343268
 
DOI:
 
10.1002/lary.25607

[PubMed - indexed for MEDLINE]

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