viernes, 8 de abril de 2016

NCTR Publications > NCTR Research Highlights

NCTR Publications > NCTR Research Highlights

National Center for Toxicological Researh log with FDA on left side

Current Highlight from April 1, 2016

Size- and Dose-Dependent Antiviral Effects of Silver Nanoparticles
NCTR scientists have demonstrated both size- and dose-dependent antiviral effects of silver nanoparticles (AgNPs) in in vitro assays using feline calicivirus (FCV) as a surrogate for human norovirus.  Treatment of cultures with 10 nanometer (nm)-sized AgNPs (at doses of 50 and 100 micrograms per milliliter [µg/mL]) completely inactivated FCV within 2-4 hours of exposure, resulting in a decrease in the viral titer, an absence of cytopathic effects in Crandell-Rees Feline Kidney cells, and a reduction in viral capsid protein levels; whereas no effect was observed with 75 and 110 nm-sized AgNPs.  The use of AgNPs as antibacterial agents has increased in consumer-use products; however, its use as an antiviral agent is still an area of active research.  This study is now available online at Foodborne Pathogens and Diseasedisclaimer icon.
For additional information, please contact Sangeeta Khare, Ph.D., Division of Microbiology, FDA/NCTR.

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