domingo, 27 de marzo de 2016

Phylogenetic Analysis of Poliovirus Sequences. - PubMed - NCBI

Phylogenetic Analysis of Poliovirus Sequences. - PubMed - NCBI



 2016;1387:227-37. doi: 10.1007/978-1-4939-3292-4_11.

Phylogenetic Analysis of Poliovirus Sequences.

Abstract

Comparative genomic sequencing is a major surveillance tool in the Polio Laboratory Network. Due to the rapid evolution of polioviruses (~1 % per year), pathways of virus transmission can be reconstructed from the pathways of genomic evolution. Here, we describe three main phylogenetic methods; estimation of genetic distances, reconstruction of a maximum-likelihood (ML) tree, and estimation of substitution rates using Bayesian Markov chain Monte Carlo (MCMC). The data set used consists of complete capsid sequences from a survey of poliovirus sequences available in GenBank.

KEYWORDS:

Bayesian MCMC; Maximum-likelihood; Phylogenetic analysis; Poliovirus evolution

PMID:
 
26983737
 
[PubMed - in process]

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