Disease-Drug Database for Pharmacogenomic-Based Prescribing.

Hussain S1, Kenigsberg BB2, Danahey K1,3, Lee YM4, Galecki PM1, Ratain MJ1,4,5, O'Donnell PH1,4,5.

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Abstract

Providers have expressed a strong desire to have additional clinical decision-support tools to help with interpretation of pharmacogenomic results. We developed and tested a novel disease-drug association tool that enables pharmacogenomic-based prescribing to treat common diseases. First, 324 drugs were mapped to 484 distinct diseases (mean number of drugs treating each disease was 4.9 [range 1-37]). Then, the disease-drug association tool was pharmacogenomically annotated, with an average of 1.8 pharmacogenomically-annotated drugs associated/disease. Applying this tool to a prospectively-enrolled >1,000 patient cohort from a tertiary medical center showed that 90% of the top ∼20 diseases in this population and ≥93% of patients could appropriately be treated with ≥1 medication with actionable pharmacogenomic information. When combined with clinical patient genotypes, this tool permits delivery of patient-specific pharmacogenomically-informed disease treatment recommendations to inform the treatment of many medical conditions of the U.S. population, a key initial step towards implementation of precision medicine. This article is protected by copyright. All rights reserved.