Melanoma: Public Health and Genomic Insights - August 20, 2015

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Melanoma

Melanoma: Public Health and Genomic Insights - August 20, 2015

CDC and Related Info

• Vital Signs: Melanoma incidence and mortality trends and projections - United States, 1982-2030MMWR, June 2 2015
• Skin cancer is the most common cancer in the United States. Most cases of melanoma, the deadliest kind of skin cancer, are caused by exposure to ultraviolet light
• Genes reported in relation to melanoma, including genomewide association studies via theHuGE Navigator

Jimmy Carter says he has melanoma that has spread to his brain, by Sam Levine, Huffington Post, August 20, 2015

Update on melanoma epigenetics.
de Unamuno Blanca et al. Curr Opin Oncol 2015 Sep (5) 420-6

Clinical utility of a blood-based BRAF(V600E) mutation assay in melanoma.
Panka DJ et al. Mol. Cancer Ther. 2014 Dec 13(12) 3210-8

Meta-analysis uncovers five additional susceptibility loci for cutaneous malignant melanoma,
Genome Web, Aug 3 [by free subscription only]

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Law ML et al, Nature Genetics, August 3, 2015

Precision oncology: Creating a genomic guide for melanoma therapy, NIH, Director's Blog, June 23, 2015

Vital Signs: Melanoma incidence and mortality trends and projections - United States, 1982-2030
MMWR, June 2 2015

Melanoma
Schadendorf D et al. Nature Reviews Disease Primers, April 23, 2015

Therapeutic advances and treatment options in metastatic melanoma
Johnson DB et al. JAMA Oncology, April 23, 2015

NRAS and BRAF mutational status and melanoma-specific survival 
Thomas N et al. JAMA Oncology, April 9, 2015

Towards predicting metastatic progression of melanoma based on gene expression data.
Li Y et al. Pigment Cell Melanoma Res 2015 Apr 3.

Inherited genetic variants associated with occurrence of multiple primary melanoma.
Gibbs DC et al. Cancer Epidemiol. Biomarkers Prev. 2015 Apr 2.

Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.
Wadt KA et al. PLoS ONE 2015 (3) e0122662

Unique genomic profile associated with pediatric uveal melanoma.
Blasi MA et al. Eur J Ophthalmol 2015 Mar 16. 0

Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study.
Kocarnik JM et al. PLoS ONE 2015 (3) e0120491

Targeted therapies in melanoma.
Moschos Stergios J et al. Surg. Oncol. Clin. N. Am. 2015 Apr (2) 347-358

Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours.
Howlin J et al. PeerJ 2015 e788

A melanoma subtype with intrinsic resistance to BRAF inhibition identified by receptor tyrosine kinases gene-driven classification.
Dugo M et al. Oncotarget 2015 Mar 10. (7) 5118-33

Genome-wide DNA methylation analysis in melanoma reveals the importance of CpG methylation in MITF regulation.
Lauss M et al. J. Invest. Dermatol. 2015 Feb 23.

Melanoma: Recent Genomic Insights - January 23, 2015

Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma.
Gerami P, et al. Clin Cancer Res. 2015 Jan 1;21(1):175-83.

New test identifies early-stage melanoma with metastatic risk, Medscape, Jan 15 [by free subscription only]

Epigenetic regulation in human melanoma: Past and future.
Sarkar D, et al. Epigenetics. 2015 Jan 14:0.

TRIB2 as a biomarker for diagnosis and progression of melanoma.
Hill R, et al.  Carcinogenesis. 2015 Jan 13.

Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients.
Ruiz C, et al. Phys Biol. 2015 Jan 9;12(1):016008

Current therapeutic leads for the treatment of melanoma: Targeted Immunotherapy in the post-genomic era.
Papanastasiou AD, et al. Curr Mol Pharmacol. 2014;7(1):33-43.

Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach.
Jiang W, et al. Oncotarget. 2014 Dec 10

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.
Aoude LG, et al. J Natl Cancer Inst. 2014 Dec 13

Melanoma genome sequencing reveals frequent PREX2 mutations.
Chroscinski D,et al. Elife. 2014 Dec 10;3.

Implementation of a companion diagnostic in the clinical laboratory: the BRAF example in melanoma.
Mancini I, et al. Clin Chim Acta. 2015 Jan 15;439:128-36

Genomic microarray analysis on formalin-fixed paraffin-embedded material for uveal melanoma prognostication.
Minca EC et al. Cancer Genet. 2014 Jul-Aug;207(7-8):306-15

Melanomagenesis; multifaceted attacks on the genome.
Bordelon JR, et al. Exp Dermatol. 2014 Nov 24.

The melanoma revolution: from UV carcinogenesis to a new era in therapeutics.
Lo JA, Fisher DE. Science. 2014 Nov 21;346(6212):945-9.

Genetic basis for clinical response to CTLA-4 blockade in melanoma.
Snyder A, et al.  N Engl J Med. 2014 Dec 4;371(23):2189-99.

Updated field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma: The MelGene database.
Antonopoulou K,et al. J Invest Dermatol. 2014 Nov 19.

IL28B polymorphism cannot predict response to interferon alpha treatment in patients with melanoma.
Probst M, et al. PLoS One. 2014 Nov 12;9(11):e112613

Melanoma Genomics: Sun Exposure and New Therapies - November 26, 2014

CDC information: Skin cancer is the most common cancer in the United States. Most cases of melanoma, the deadliest kind of skin cancer, are caused by exposure to ultraviolet light

Risk factors for melanoma include genes and family health history, from the National Cancer Institute

A special supplement from Nature Outlook:  Melanoma — the deadliest form of skin cancer is on the rise in many parts of the world. But new treatments, and efforts to tell people how to prevent it, could mean we will soon gain the upper hand on the disease. November, 2014

The cancer that rises with the sun.
David Holmes Nature, 515, S110–S111, 20 November 2014

Risk factors: Riddle of the rays
Cassandra Willyard, Nature 515, S112–S113 (20 November 2014)

Epidemiology, risk factors, prevention, and early detection of melanoma.
Azoury SC, Lange JR. Surg Clin North Am. 2014 Oct;94(5):945-62

Did you know? 389 genes have been reported in relation to melanoma risk and outcomes, including 33 genomewide association studies. To find out more, check out the HuGE Navigator

Recent Genomic Insights

Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes.
Anna E. Barón et al. CEBP, November 18, 2014

Genes and sun behaviors during childhood may play large role in future melanoma risk, American Association for Cancer Research, November 19, 2014

Editorial: Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma.
NEJM, November 19, 2014.  

Genetic basis for clinical response to CTLA-4 blockade in melanoma.
NEJM, November 19, 2014