Pertussis: Genomics and Public Health - August 21, 2015

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Pertussis

Pertussis: Genomics and Public Health - August 21, 2015

CDC and Related Info

• Pertussis (Whooping Cough)
• Using AMD technologies to understand changes in virulence of Bordetella pertussis and find effective vaccine components and diagnostic markers
• Genome sequences of 28 Bordetella pertussisU.S. outbreak strains dating from 2010 to 2012.Genome Announcement, December 2013
• Population diversity among Bordetella pertussis isolates, United States, 1935–2009,Emerging Infectious Diseases (2012)

Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.
Xu Y et al. Sci Rep 2015 12888

Towards improved accuracy of Bordetella pertussis nucleic acid amplification tests.
Loeffelholz M et al. J. Clin. Microbiol. 2012 Jul (7) 2186-90

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that Vaccine antigen genes are unusually fast evolving.
Sealey Katie L et al. J. Infect. Dis. 2015 Jul 15. (2) 294-301

Pertussis across the globe: recent epidemiologic trends fom 2000-2013.
Tan T et al. Pediatr. Infect. Dis. J. 2015 Jun 16.

Complete genome sequence of bordetella pertussis D420.
Boinett CJ et al. Genome Announc 2015 (3)

Multiplex real-time PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis.
Kolodkina V et al. Iran J Microbiol 2014 Jun (3) 140-8

Whole-genome sequence of a bordetella pertussis Brazilian vaccine strain.
Akamatsu MA et al. Genome Announc 2015 (1)

CDC Information: Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis

A total of 9,935 cases of pertussis with onset in 2014 were reported in California, during Jan. 1 through Nov. 26, MMWR, December 5, 2014

CDC information:  Using AMD technologies to understand changes in virulence of Bordetella pertussis and find effective vaccine components and diagnostic markers

CDC paper: Genome sequences of 28 Bordetella pertussis U.S. outbreak strains dating from 2010 to 2012. 
Genome Announcement, December 2013

CDC paper:  Population diversity among Bordetella pertussis isolates, United States, 1935–2009, 
Emerging Infectious Diseases (2012)

Find out which genes have been studied in relation to pertussis occurrence and outcomes from theHuGE Navigator