Obesity: Public Health and Genomic Insights - August 25, 2015

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Obesity

Obesity: Public Health and Genomic Insights - August 25, 2015

CDC and Related Info

• CDC information on obesity
• New CDC state obesity map now available
• Genes reported in relation to obesity, including genomewide association studies via theHuGE Navigator

Genetic causal attributions for weight status and weight loss during a behavioral weight gain prevention intervention
McVay MA et al,Genetics in Medicine, August 20, 2015

It's complicated: genomics, obesity and diabetes, Genomics Education Program, August 17, 2015

FTO obesity variant circuitry and adipocyte browning in humans.
Claussnitzer M et al. N. Engl. J. Med. 2015 Aug 19.

Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders.
Gervasini G et al. Pharmacogenomics 2015 Aug 12. 1-19

Behavioral susceptibility to obesity: Gene-environment interplay in the development of weight.
Llewellyn C et al. Physiol. Behav. 2015 Jul 10.

Epigenetics of obesity: beyond the genome sequence.
Cordero P et al. Curr Opin Clin Nutr Metab Care 2015 Jul (4) 361-6

Epigenetics of obesity: beyond the genome sequence.
Cordero P et al. Curr Opin Clin Nutr Metab Care 2015 Jul (4) 361-366

Early factors leading to later obesity: interactions of the microbiome, epigenome, and nutrition.
Chang L et al. Curr Probl Pediatr Adolesc Health Care 2015 May (5) 134-42

Obesity genes, personalized medicine, and public health policy
Caulfield T , Current Obesity Reports, June 2015

What is obesity? Metabolic signatures offer new comprehensive view, Francis Collins, NIH Director Blog, May 12, 2015

Genomic knowledge is power in the fight against obesity, by Bruce Agnew, NHGRI, May 2015

Transgenerational inheritance of metabolic disease.
Stegemann R et al. Semin. Cell Dev. Biol. 2015 Apr 29.

Epigenome-wide association study (EWAS) of BMI, BMI change, and waist circumference in African American adults identifies multiple replicated loci.
Demerath EW et al. Hum. Mol. Genet. 2015 May 1.

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.
Bonhoure N et al. Genes Dev. 2015 May 1. (9) 934-47

The role of the gut microbiota in metabolic health.
Janssen AW et al. FASEB J. 2015 Apr 28.

Interactions between obesity-related copy number variants and dietary behaviors in childhood obesity.
Zhang D et al. Nutrients 2015 (4) 3054-66

The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity.
Chen H-H et al. Int J Obes (Lond) 2015 Apr 24.

Mothers' guilt responses to children's obesity risk feedback.
Persky S et al. J Health Psychol 2015 May (5) 649-58

A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder.
Hung Chi-Fa et al. BMC Med 2015 86

Genome-wide screen of DNA methylation identifies novel markers in childhood obesity.
Ding Xu et al. Gene 2015 Apr 12.

Obesity: interactions of genome and nutrients intake.
Doo Miae et al. Prev Nutr Food Sci 2015 Mar (1) 1-7

Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat.
Ollikainen M et al. Clin Epigenetics 2015 (1) 39

Genome-wide expression in visceral adipose tissue from obese prepubertal children.
Aguilera CM et al. Int J Mol Sci 2015 (4) 7723-37

Obesity: New Genomic Insights - March 30, 2015

The Hunger Genes: Pathways to obesity
van der Klaauw AA et al. Cell, March 26, 2015

Polymorphisms in endothelin system genes, arsenic levels and obesity risk.
Martínez-Barquero V et al. PLoS ONE 2015 (3) e0118471

Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals.
Nead KT et al. Hum. Mol. Genet. 2015 Mar 17.

Gene-environment interactions and obesity: recent developments and future directions.
Huang T et al. BMC Med Genomics 2015 530

Genetic studies yield new insights into obesity by Dr. Francis Collins, NIH Director's Blog, Feb 19

Weighty impact of new genetic fat map , by Rebecca Burbridge, PHG Foundation, Feb 13

Genetic studies of body mass index yield new insights for obesity biology.
Locke Adam E et al. Nature 2015 Feb 12. (7538) 197-206

New genetic loci link adipose and insulin biology to body fat distribution.
Shungin Dmitry et al. Nature 2015 Feb 12. (7538) 187-96

Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women.
Maples Jill M et al. Physiol. Genomics 2015 Feb 10.

Associations between TRPV4 genotypes and body mass index in Taiwanese subjects.
Duan De-Min et al. Mol. Genet. Genomics 2015 Feb 3.

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Wessel Jennifer et al. Nat Commun 2015 5897

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
Mahajan Anubha et al. PLoS Genet. 2015 Jan (1) e1004876

Obesity breakthrough: Researchers identify new genetic markers for obesity in largest-ever genomic study on the disease,  International Business Times, Feb 11

Obesity: Recent Public Health and Genomic Insights- January 8, 2015

Life years lost and lifetime healthcare expenditures associated with diabetes in the U.S., National Health Interview Survey, 1997-2000.
Leung MM, et al. Diabetes Care. 2014 Dec 31. 
 
Cohort of birth modifies the association between FTO genotype and BMI. 
James Niels Rosenquist, et al. PNAS, December 2014

Gene linked to obesity hasn’t always been a problem, study finds, New York Times, Dec 31, 2014

FTO and obesity: mechanisms of association.
Zhao X, et al. Curr Diab Rep. 2014;14(5):486

Nutritional genomics and metabolomics in obesity and type 2 diabetes. 
Frank B Hu et al. BMC Genomics 2014, 15(Suppl 2):O10

Advances in exercise, fitness, and performance genomics in 2013.
Wolfarth B, et al. Med Sci Sports Exerc. 2014;46(5):851-9

Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.
Basile KJ, et al. Int J Endocrinol. 2014;2014:769671

Obesity: Genes, Environment & Public Health - September 11, 2014

CDC media advisory: New CDC state obesity map now available, Sep 4

CDC information: Obesity prevalence in 2013 varies across states and regions

CDC information on obesity: Strategies to make healthy eating and active living accessible and affordable for everyone

CDC information: Genomics and health- Behavior, environment, and genetic factors all have a role in causing people to be overweight and obese

Did you know? More than 1660 genes have been reported in relation to obesity occurrence and outcomes including 178 genomewide association studies? To find out more, visit the HuGE Navigator

Genes are not destiny. Obesity-promoting genes in an obesity-promoting world, Harvard School of Public Health 

It's not all in the genes, Tim Caulfield, Policy Options, Jul 2014

The application of public health genomics to the prevention and management of obesity in the UK, PHG Foundation (2013)

Ancient famine-fighting genes can't explain obesity. Scientists look beyond calorie-hoarding genes to understand widening waistlines, by Laura Beil, Science News, Sep 5