High Blood Pressure: Public Health and Genomic Insights - August 24, 2015

Genomics|Features|High Blood Pressure

High Blood Pressure

High Blood Pressure: Public Health and Genomic Insights - August 24, 2015

CDC and Related Info

• Million Hearts launches annual blood pressure control challenge
• Sodium intake among U.S. adults - 26 States, the District of Columbia, and Puerto Rico, 2013MMWR, July 2, 2015
• High Blood Pressure
• Genes reported in relation to hypertension, including genomewide association studies via theHuGE Navigator

CDC information: Million Hearts launches annual blood pressure control challenge

Pharmacogenomics of hypertension and heart disease.
Arwood MJ et al. Curr. Hypertens. Rep. 2015 Sep (9) 586

Associations between genetic variants of the natriuretic peptide system and blood pressure response to dietary sodium intervention: The GenSalt study.
Chen S et al. Am. J. Hypertens. 2015 Jul 29.

The relation between ACE D/I and CYP11B2 C-344T polymorphisms and parameters of arterial stiffness in the context of renal sodium handling.
Cwynar M et al. Blood Press. 2015 Jul 29. 1-11

Heritability of ambulatory and office blood pressure in the Swiss population.
Alwan H et al. J. Hypertens. 2015 Jul 22.

Genetics of resistant hypertension: a novel pharmacogenomics phenotype.
El Rouby N et al. Curr. Hypertens. Rep. 2015 Sep (9) 583

Sodium intake among U.S. adults - 26 States, the District of Columbia, and Puerto Rico, 2013
MMWR, July 2, 2015

The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies.
Bruneau ML et al. J Sci Med Sport 2015 Jun 5.

Mechanisms of salt-sensitive hypertension.
Luzardo L et al. Curr Hypertens Rev 2015 (1) 14-21

Fetal programming and epigenetic mechanisms in arterial hypertension.
Scherrer U et al. Curr. Opin. Cardiol. 2015 Jul (4) 393-7

Genetic and molecular aspects of hypertension.
Padmanabhan S et al. Circ. Res. 2015 Mar 13. (6) 937-59

The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment.
Rayner B et al. Int J Mol Sci 2015 (3) 5741-9

Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors?
Rankinen T et al. Circ. Res. 2015 Feb 27. (5) 909-22

Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism.
Scholl UI et al. Elife Apr 24;4:e06315.

PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies.
Tran NT et al. Front Genet 2015 Apr 8;6:136.

Association of adiponectin with type 2 diabetes and hypertension in African American men and women: the Jackson Heart Study.
Davis SK et al. BMC Cardiovasc Disord 2015 Feb 25;15:13.

Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Huan T et al. Mol. Syst. Biol. 2015 Apr 16;11(1):799.

The impact of angiotensin receptor blockers on arterial stiffness: a meta-analysis.
Peng F et al. Hypertens. Res. 2015 Apr 9.

Non-coding RNAs and hypertension-unveiling unexpected mechanisms of hypertension by the dark matter of the genome.
Murakami K et al. Curr Hypertens Rev 2015;11(2):80-90.

Genomic research in postmenopausal hypertension.
Thomopoulos C et al. J Clin Hypertens (Greenwich) 2015 Jul;17(7):557.

The ACE2/Apelin signaling, MicroRNAs, and hypertension.
Chen LJ et al. Int J Hypertens 2015;2015:896861.

Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study.
Yamada Y et al. Int. J. Mol. Med. 2015 May (5) 1189-98

A meta-analysis of gene expression signatures of blood pressure and hypertension.
Huan T et al. PLoS Genet. 2015 Mar (3) e1005035

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.
Rudemiller NP et al. Hypertension 2015 May (5) 1111-7

CYP17A1 and blood pressure reactivity to stress in adolescence.
Van Woudenberg M et al. Int J Hypertens 2015 734586

High Blood Pressure, Genomics & Family Health History - March 12, 2014

CDC information: About 1 in 3 U.S. adults—or 67 million people—have high blood pressure. Only about half (47%) of people with high blood pressure have their condition under control

High blood pressure runs in families. Collect and act on your family health history  [PDF 94.84 KB]

Did you know? More than 4000 publications have reported since 2001 on the relation between genetic variation and risk and outcomes of hypertension? These include 97 genomewide association studies. To find out more, visit the HuGE Navigator