Human Papilloma Virus: Genomic Insights - August 3, 2015

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Human Papilloma Virus

Human Papilloma Virus: Genomic Insights - August 3, 2015

CDC Info

• Many adolescents still not getting HPV vaccine
• Human Papillomavirus (HPV) Information Portal
• HPV and Cancer
• Protect the Next Generation: Recommend the HPV Vaccine

Prognostic implication of persistent human papillomavirus type 16 DNA detection in oral rinses for human papillomavirus–related oropharyngeal carcinoma
Retting EM et al. JAMA Oncology, July 30, 2015

NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome.
Chandrani P et al. Br. J. Cancer 2015 Jun 9. (12) 1958-65

Integrating genomics in head and neck cancer treatment: Promises and pitfalls.
Thariat J et al. Crit. Rev. Oncol. Hematol. 2015 Apr 18.

A systematic investigation of the contribution of genetic variation within the MHC region to HPV seropositivity.
Chen D et al. Hum. Mol. Genet. 2015 May 1. (9) 2681-8

Comparison between single PCR and nested PCR in detection of human papilloma viruses in paraffin-embedded OSCC and fresh oral mucosa.
Jalouli M et al. In Vivo 2015 Jan-Feb (1) 65-70

Human papilloma virus (HPV) modulation of the HNSCC epigenome.
Stephen JK et al. Methods Mol. Biol. 2015 369-79

Cancer-associated infectious agents and epigenetic regulation.
Vedham V et al. Methods Mol. Biol. 2015 333-54

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.
Seiwert TY et al. Clin. Cancer Res. 2015 Feb 1. (3) 632-41

Many adolescents still not getting HPV vaccine: Large vaccination increases in some states offer clues to effective interventions

Human Papilloma Virus: Cervical Cancer and DNA Testing - January 23, 2015

CDC information: Human Papillomavirus (HPV) Information Portal

CDC Expert Commentary Podcast: Protect the Next Generation: Recommend the HPV Vaccine,Tom Frieden, CDC Director, August 18, 2014

CDC information: Discover the link between HPV and Cancer

Recent Insights

Performance of self-collected cervical samples in screening for future precancer using human papillomavirus DNA testing.
Porras C, et al. J Natl Cancer Inst. 2014 Dec 5;107(1):400.

Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance.
Huh WK, et al. Obstet Gynecol. 2015 Jan 7

NCI paper: Cancer-associated infectious agents and epigenetic regulation.
Vedham V, Verma M.  Methods Mol Biol. 2015;1238:333-54

TGFβ receptor 1: An immune susceptibility gene in HPV-associated cancer.
Levovitz C, et al. Cancer Res. 2014 Dec 1;74(23):6833-44

A comprehensive review of dysregulated miRNAs involved in cervical cancer.
Sharma G, et al. Curr Genomics. 2014 Aug;15(4):310-23

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism 
Zheng Hu et al. Nature Genetics, January 12, 2015