Epidemiology in the Age of Genomics: New Directions - August 11, 2015

Genomics|Features|Epidemiology

Epidemiology

Epidemiology in the Age of Genomics: New Directions - August 11, 2015

CDC and Related Info

• The future of epidemiology in the age of precision medicine: Cancer, cardiovascular disease, and beyond,
• Charting a future for epidemiologic training.(2015)
• Evolution of the "Drivers" of translational cancer epidemiology: Analysis of funded grants and the literature(2014)
• Opportunities for translational epidemiology: the important role of observational studies to advance precision oncology(2015)
• A primer series on -omic technologies for the practice of epidemiology(2014)
• 100,000 Studies: A Milestone for Human Genome Epidemiology and the HuGE Navigator
• Updated guidance on Human Genome Epidemiology (HuGE) reviews and meta-analyses of genetic associations(2014)
• Human Genome Epidemiology Network (HuGENet)
• The HuGE Navigator Database

New blog post: The future of epidemiology in the age of precision medicine: Cancer, cardiovascular disease, and beyond, Muin J Khoury and Gina S Wei (August 11, 2015)

Use of the microbiome in the practice of epidemiology: A primer on -omic technologies
Foxman B et al. Am J Epidemiol, May 29 2015

CDC paper: Charting a future for epidemiologic training.
Brownson Ross C et al. Ann Epidemiol 2015 Jun (6) 458-65

Epidemiology in the era of big data.
Mooney Stephen J et al. Epidemiology 2015 Mar 6.

CDC paper: Evolution of the "drivers" of translational cancer epidemiology: Analysis of funded grants and the literature
Lam T, et al. Am J Epidemiol, March 11, 2015

CDC paper: Opportunities for translational epidemiology: the important role of observational studies to advance precision oncology.
Marrone Michael et al. Cancer Epidemiol. Biomarkers Prev. 2015 Mar (3) 484-9

Strategic transformation of population studies: Recommendations of the Working Group on Epidemiology and Population Sciences From the National Heart, Lung, and Blood Advisory Council and Board of External Experts.
Véronique L Roger et al. Am. J. Epidemiol. 2015 Mar 4.

Invited commentary: Future of population studies-defining research priorities and processes.
Vasan Ramachandran S et al. Am. J. Epidemiol. 2015 Mar 4.

Strategic transformation of population studies:  [PDF 233.51 KB] NHLBI Council/BEE Working Group's Recommendations to the NHLBI Advisory Council October 22, 2014

Is integrative epidemiology next-gen epidemiology, NCI Blog post

Toward a road map for global -omics: A primer on -omic technologies for the practice of epidemiology. 
Steven S. Coughlin, Am J Epidemiology, November 18, 2014

For additional cancer epidemiology matters blog posts

Omics and the Practice of Epidemiology - March 20, 2015

New CDC editorial: A primer series on -omic technologies for the practice of epidemiology
Muin J. Khoury. American Journal of Epidemiology, June 24, 2014

Epidemiologic design and analysis for proteomic studies: A primer on -omic technologies
Mischak H et al. Am J Epidemiology, March 18, 2015

Design and analysis of metabolomics studies in epidemiological research: A primer on -omic technologies. 
Ioanna Tzoulaki et al. American Journal of Epidemiology, June 24, 2014

Design and analysis for studying microRNAs in human disease: A primer on -omic technologies. 
Viswam S. Nair et al. American Journal of Epidemiology, June 24, 2014 

Supersize me: how whole-genome sequencing and big data are transforming epidemiology
Rowland R. Kao et al. PLOS Microbiology, March 2014

Opportunities and challenges for selected emerging technologies in cancer epidemiology: Mitochondrial, epigenomic, metabolomic, and telomerase profiling. 
Mukesh Verma et al. Cancer Epidemiology, Biomarkers and Prevention (2013)

Epigenetic research in cancer epidemiology: Trends, opportunities, and challenges. 
Mukesh Verma et al. Cancer Epidemiology Biomarkers and Prevention (2014)

NCI-CDC paper: Transforming epidemiology for 21st century population health in the age of genomics and big data, CEBP (2013)

Human Genome Epidemiology Navigator: A Resource for Research & Practice - February 9, 2015

New CDC blog post: 100,000 Studies: A Milestone for Human Genome Epidemiology and the HuGE Navigator,Marta Gwinn, Feb 9

CDC information: What is human genome epidemiology?

The Human Genome Epidemiology Navigator provides access to a continuously updated knowledge base in human genome epidemiology, including information on population prevalence of genetic variants, gene-disease associations, gene-gene and gene- environment interactions, and evaluation of genetic tests

Future of Epidemiology: Assessing New Genome-based Technologies - January 20, 2015

Celebrating the 30th anniversary of genetic epidemiology: How to define our scope? 
Ziegler A, König IR. Genet Epidemiol. 2014 Jul;38(5):379-80.

Expanding epigenomics to archived FFPE tissues: An evaluation of DNA repair methodologies. 
Erin M. Siegel et al. Cancer Epidemiol Biomarkers Prev December 2014 23:12 2622-2631;

Suitability of circulating miRNAs as potential prognostic markers in colorectal cancer. 
Jonas Ristau et al.  Cancer Epidemiol Biomarkers Prev December 2014 23:12 2632-2637;

Quantification of circulating miRNAs by droplet digital PCR: Comparison of Evagreen- and Taqman-based chemistries. 
Elena Miotto, et al.  Cancer Epidemiol Biomarkers Prev December 2014 23:12 2638-2642;

Effects of preanalytic variables on circulating microRNAs in whole blood. 
Hua Zhao, et al.  Cancer Epidemiol Biomarkers Prev December 2014 23:12 2643-2648; 

Assay reproducibility and interindividual variation for 15 serum estrogens and estrogen metabolites measured by liquid chromatography–tandem mass spectrometry. 
Barbara J. Fuhrman et al.  Cancer Epidemiol Biomarkers Prev December 2014 23:12 2649-2657;

Improving power to detect changes in blood miRNA expression by accounting for sources of variability in experimental designs. 
Sarah I. Daniels, et al. Cancer Epidemiol Biomarkers Prev December 2014 23:12 2658-2666;

Measurement of telomere length: A new assay using QuantiGene chemistry on a Luminex platform. 
Muhammad G. Kibriya, et al.  Cancer Epidemiol Biomarkers Prev December 2014 23:12 2667-2672;

Usefulness of saliva samples for biomarker studies in radiation research. 
Eileen Pernot, et al. Cancer Epidemiol Biomarkers Prev December 2014 23:12 2673-2680;

SEER Cancer Registry biospecimen research: Yesterday and tomorrow. 
Sean F. Altekruse, et al. Cancer Epidemiol Biomarkers Prev December 2014 23:12 2681-2687;

DNA from nails for genetic analyses in large-scale epidemiologic studies. 
Janneke G.F. Hogervorst, et al. Cancer Epidemiol Biomarkers Prev December 2014 23:12 2703-2712;

The landscape of microRNA, piwi-interacting RNA, and circular RNA in human saliva
Jae Hoon Bahn et al. Clinical Chemistry, January 2015

Human Genome Epidemiology: Meta Analyses and Genomewide Association Studies - September 4, 2014

New CDC paper: Updated guidance on Human Genome Epidemiology (HuGE) reviews and meta-analyses of genetic associations. 
Marta Gwinn et al. American Journal of Epidemiology, August 26, 2014

Did you know? The HuGE Navigator Database has >96000 curated genetic association articles including  >3000 genomewide association studies and >3000 meta analyses of gene-disease associations

CDC paper: A systematic review of cancer GWAS and candidate gene meta-analyses reveals limited overlap but similar effect sizes. 
Chang CQ, et al. Eur J Hum Genet. 2014 Mar;22(3):402-8. 

The CDC Human Genome Epidemiology Network (HuGENet) provides a population perspective on human genetic variation in health and disease through data synthesis, interpretation and dissemination