Clostridium difficile: Genomics and Public Health - July 27, 2015

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Clostridium difficile

Clostridium difficile: Genomics and Public Health - July 27, 2015

CDC Info

• Nearly half a million Americans suffer from C. difficile infections in single year
• Clostridium difficile Infection
• CDC Vital Signs:Stopping C. difficile infections
• Development and validation of an internationally-standardized, high-resolution capillary gel-based electrophoresis PCR-ribotyping protocol for Clostridium difficile.Fawley Warren N et al.PLoS ONE 2015 (2) e0118150

Diversity and evolution in the genome of Clostridium difficile.
Knight Daniel R et al.Clin. Microbiol. Rev.2015 Jul (3) 721-741

Genomic epidemiology of a protracted hospital outbreak caused by a toxin A negative, Clostridium difficile sublineage PCR Ribotype 017 strain in London, England.
Cairns MD et al. J. Clin. Microbiol. 2015 Jul 15.

Clostridium difficile infection.
Leffler DA et al. N. Engl. J. Med. 2015 Apr 16. (16) 1539-48

Toward a true bacteriotherapy for Clostridium difficile infection.
Rupnik M et al. N. Engl. J. Med. 2015 Apr 16. (16) 1566-8

CDC information: Nearly half a million Americans suffer from C. difficile infections in single year

CDC information: Clostridium difficile Infection

CDC Vital Signs: Stopping C. difficile infections

CDC paper: Development and validation of an internationally-standardized, high-resolution capillary gel-based electrophoresis PCR-ribotyping protocol for Clostridium difficile.
Fawley Warren N et al. PLoS ONE 2015 (2) e0118150

Diagnosis and treatment of C. difficile in adults. This systematic review summarizes the diagnosis and treatment of Clostridium difficile infection. 
Bagdasariann , et al. JAMA, January 27, 2015

Diagnostic pitfalls in Clostridium difficile infection.
Planche T, Wilcox M. Infect Dis Clin North Am. 2015 Jan 13.

The genome of Clostridium difficile 5.3. 
Aaron E Darling, et al.  Gut Pathog. 2014 Feb 24;6(1):4.

Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011
Knetsch CW, et al. Euro Surveill. 2014;19(45):pii=20954.

Clostridium difficile isolates with high linezolid MICs harbor the multiresistance gene cfr
Marin M, et al. Antimicrob Agents Chemother 2015; 59(1): 586-589.

Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children.
Ling Z, et al. Sci Rep. 2014 Dec 15;4:7485

Evolutionary history of the Clostridium difficile pathogenicity locus. 
Kate E. Dingle et al. Genome Biol Evol (2014) 6 (1): 36-52.

Diverse sources of C. difficile infection identified on whole-genome sequencing. 
David W. Eyre, et al. N Engl J Med. 2013 Sep 26;369(13):1195-205.

Microevolutionary analysis of Clostridium difficile genomes to investigate transmission.
Didelot X, et al. Genome Biol. 2012 Dec 21;13(12):R118

Sequencing of bacterial genomes: principles and insights into pathogenesis and development of antibiotics. 
Donkor ES. Genes (Basel). 2013 Oct 14;4(4):556-72.

Fourteen-genome comparison identifies DNA markers for severe-disease-associated strains of Clostridium difficile.
Forgetta V, et al. J Clin Microbiol. 2011 Jun;49(6):2230-8.