Gene-Lifestyle and Gene-Pharmacotherpy Interaction... [Curr Vasc Pharmacol. 2010] - PubMed result

Curr Vasc Pharmacol. 2010 Dec 14. [Epub ahead of print]
Gene-Lifestyle and Gene-Pharmacotherpy Interactions in Obesity and Its Cardiovascular Consequences.

Franks PW, Poveda A.

Department of Clinical Sciences, Skåne University Hospital, Lund University, 20502 Malmo, Sweden. paul.franks@med.lu.se.

Abstract

Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variation may modify the relationship between lifestyle behaviors and weight loss or weight gain. Similar observations have also emerged from pharmacogenetic studies. The literature includes several reports from these studies, but few examples of interactions have been adequately replicated. In this review we introduce the topics of population genetics research and gene x environment interaction. We also provide a systematic review of the published literature on gene x lifestyle (physical activity and dietary factors) and gene x drug interactions in relation to obesity. Finally, we overview the scope and findings from these studies and discuss some of their strengths and limitations.

PMID: 21143160 [PubMed - as supplied by publisher]
Gene-Lifestyle and Gene-Pharmacotherpy Interaction... [Curr Vasc Pharmacol. 2010] - PubMed result