Components of family history associated with women... [Genet Med. 2010] - PubMed result

Genet Med. 2010 Dec 10. [Epub ahead of print]
Components of family history associated with women's disease perceptions for cancer: A report from the Family Healthware™ Impact Trial.

Rubinstein WS, Oʼneill SM, Rothrock N, Starzyk EJ, Beaumont JL, Acheson LS, Wang C, Gramling R, Galliher JM, Ruffin MT 4th.

From the 1Department of Medicine, Division of Genetics, 2NorthShore University HealthSystem (previously Evanston Northwestern Healthcare), Evanston, Illinois; 3Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois; Departments of 4Medicine and 5Medical Social Sciences, Northwestern University, Chicago, Illinois; 6Department of Epidemiology, School of Public Health, University of Illinois at Chicago, Chicago, Illinois; 7Department of Family Medicine, Research Division, Case Western Reserve University, Cleveland, Ohio; 8University Hospitals Case Medical Center, Cleveland, Ohio; 9Case Comprehensive Cancer Center, Cleveland, Ohio; 10Department of Social and Behavioral Sciences, School of Public Health, Boston University, Boston, Massachusetts; 11Department of Family Medicine, University of Rochester, Rochester, New York; 12American Academy of Family Physicians' National Research Network, Leawood, Kansas; and 13Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.

Abstract

PURPOSE: To determine the specific components of family history and personal characteristics related to disease perceptions about breast, colon, and ovarian cancers.

METHODS: Baseline, cross-sectional data on 2,505 healthy women aged 35-65 years enrolled from 41 primary care practices in the cluster-randomized Family Healthware™ Impact Trial, assessed for detailed family history and perceived risk, perceived severity, worry, and perceived control over getting six common diseases including breast, colon, and ovarian cancers.

RESULTS: Participants provided family history information on 41,841 total relatives. We found evidence of underreporting of paternal family history and lower perceived breast cancer risk with cancer in the paternal versus maternal lineage. We observed cancer-specific perceived risks and worry for individual family history elements and also found novel "spillover" effects where a family history of one cancer was associated with altered disease perceptions of another. Having a mother with early-onset breast or ovarian cancer was strongly associated with perceived risk of breast cancer. Age, parenthood, and affected lineage were associated with disease perceptions and ran counter to empiric risks.

CONCLUSIONS: Understanding patients' formulation of risk for multiple diseases is important for public health initiatives that seek to inform risk appraisal, influence disease perceptions, or match preventive interventions to existing risk perceptions.

PMID: 21150785 [PubMed - as supplied by publisher]
Components of family history associated with women... [Genet Med. 2010] - PubMed result