Pharmacogenomics of beta1-adrenergic receptor poly... [Heart Fail Clin. 2010] - PubMed result

Heart Fail Clin. 2010 Jan;6(1):27-33.

Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure.
Liggett SB.

Cardiopulmonary Genomics Program, University of Maryland School of Medicine, 20 Penn Street, HSF-II, Baltimore, MD, USA. sligg001@umaryland.edu

The major pathologic beta(1)-adrenergic receptor (beta(1)-AR) subtype in heart failure is beta(1)-AR. The authors' laboratory has thus pursued genetic variation of the beta(1)-AR gene at the molecular, cellular, physiologic, and clinical levels as the potential basis for interindividual variability in the response to beta-blocker treatment during heart failure. This article reviews these findings, with emphasis on mechanism of action and future directions.

PMID: 19945058 [PubMed - in process]

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Pharmacogenomics of beta1-adrenergic receptor poly... [Heart Fail Clin. 2010] - PubMed result