Pharmacogenetic profiling in the treatment of hear... [Transl Res. 2009] - PubMed result

Transl Res. 2009 Dec;154(6):295-302. Epub 2009 Aug 12.

Pharmacogenetic profiling in the treatment of heart disease.
Dorn GW 2nd.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, Mo.

Pharmacogenetics is the study of gene-drug interactions. In the post-Human Genome era, and with the realization that personal genotypes differ by millions of bases (gene polymorphisms), the application of genetics to explain interindividual differences in clinical drug response seems to offer great promise. Here, recent basic and translational developments in pharmacogenetic profiling of beta-blocker response in heart failure are reviewed in the context of the possible consequences of such advances on drug development and clinical therapeutics.

PMID: 19931195 [PubMed - in process]

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Pharmacogenetic profiling in the treatment of hear... [Transl Res. 2009] - PubMed result