Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy | Cancer & Metabolism | Full Text

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy | Cancer & Metabolism | Full Text

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support p...

Authors:Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova…

Citation:Cancer & Metabolism 2020 8:1

Content type:Research

Published on: 2 January 2020

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