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miércoles, 5 de febrero de 2020
Medical News | Medical Articles: Lipsomes for Brain Drug Delivery
Alzheimer’s disease, in spite of being the sixth main cause of death in the US, has only five drug treatments approved, due to the failure of drug development for central nervous system (CNS) diseases in clinical trials. This is caused by the selective permeability of the blood-brain-barrier (BBB).
It is known that Alzheimer’s disease is caused by the formation of amyloid plaques and tau tangles in the brain. A novel compound shows promise in preventing amyloid formation, fighting Alzheimer’s disease development.
The first symptoms of a head injury such as confusion, memory loss and changes in speech and vision can resemble those seen in dementia. Depending on how severe the injury is, such symptoms may resolve quickly, last a long time or never completely go away.
Dementia, a neurodegenerative and debilitating illness can take a toll on the life of older adults. In a recent report, the number of patients with dementia being rushed to emergency rooms rose by a staggering 35 percent in five years.
A common pathological hallmark of many neurodegenerative diseases is the presence of oxidative stress caused by an accumulation of reactive oxygen species (ROS).
One of the most fascinating scientific challenges is to enhance human cognitive abilities. Research interests have been focused on preventing age-related cognitive decline and sustaining optimal cognitive performance in cognitively demanding situations.
Individuals at risk for Alzheimer's disease (AD) because of family history or genetic predisposition who engaged in six months of aerobic exercise training improved their brain glucose metabolism and higher-order thinking abilities (e.g., planning and mental flexibility) called executive function; these improvements occurred in conjunction with increased cardiorespiratory fitness.
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