Ahead of Print - New Delhi Metallo-β-Lactamase 5–Producing Klebsiella pneumoniae Sequence Type 258, Southwest China, 2017 - Volume 25, Number 6—June 2019 - Emerging Infectious Diseases journal - CDC

Ahead of Print - New Delhi Metallo-β-Lactamase 5–Producing Klebsiella pneumoniae Sequence Type 258, Southwest China, 2017 - Volume 25, Number 6—June 2019 - Emerging Infectious Diseases journal - CDC

Volume 25, Number 6—June 2019

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New Delhi Metallo-β-Lactamase 5–Producing Klebsiella pneumoniae Sequence Type 258, Southwest China, 2017

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More articles on Antimicrobial Resistance

Xin Zhang1, Weimin Wang1, Hua Yu1, Min Wang, Haifang Zhang, Jingnan Lv, Yi-Wei Tang, Barry N. Kreiswirth, Hong Du , and Liang Chen

Author affiliations: Sichuan Academy of Medical Science, Sichuan, China (X. Zhang, H. Yu); Sichuan Provincial People’s Hospital, Sichuan (X. Zhang, H. Yu); Memorial Sloan Kettering Cancer Center, New York, New York, USA (X. Zhang, Y.-W. Tang); The Second Affiliated Hospital of Soochow University, Suzhou, China (W. Wang, M. Wang, H. Zhang, J. Lv, H. Du); Rutgers University, Newark, New Jersey, USA (B.N. Kreiswirth, L. Chen)

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Abstract

We isolated a New Delhi metallo-β-lactamase 5 (NDM-5)–producing Klebsiella pneumoniae sequence type (ST) 258 strain in southwest China during 2017. The blaNDM-5 gene was acquired by horizontal plasmid transfer from NDM-5–producing Escherichia coli. We identified genomic characteristics in ST258 strains that differed from those of global K. pneumoniae carbapenemase–producing strains.

Carbapenem-resistant Klebsiella pneumoniae has emerged as one of the major multidrug-resistant bacterial pathogens worldwide. The international spread of this pathogen has been linked to a few high-risk clone group (CG) strains, including CG258, CG14/15, CG17/20, CG43, CG147, and CG307 (1), of which CG258 is the most widely spread. Within CG258, sequence type (ST) 258 predominates in North America and Europe, but ST11 is the primary carbapenem-resistant K. pneumoniae clone in eastern Asia, especially in China (2–4).

In recent years, K. pneumoniae ST11 strains have been increasingly identified in North America. In contrast, ST258 strains are still rarely reported in China (5). Unlike other high-risk clones, such as ST11, that harbor different types of carbapenemases, carbapenem-resistant K. pneumoniae ST258 are almost exclusively associated with K. pneumoniae carbapenemase (KPC) (6). We report identification of a New Delhi metallo-β-lactamase 5 (NDM-5)–producing K. pneumoniae ST258 strain from Chengdu in southwest China.