sábado, 1 de diciembre de 2018

Interview With a Scientist – Rommie Amaro: Computational and Theoretical Model Builder | Biomedical Beat Blog - National Institute of General Medical Sciences

Interview With a Scientist – Rommie Amaro: Computational and Theoretical Model Builder | Biomedical Beat Blog - National Institute of General Medical Sciences

Source: Eva Mutunga and Kate Klein, University of the District of Columbia and National Institute of Standards and Technology. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License.​



Interview With a Scientist – Rommie Amaro: Computational and Theoretical Model Builder

Many researchers who search for anti-cancer drugs have labs filled with chemicals and tissue samples. Not Rommie Amaro Link to external web site. Her work uses computers to analyze the shape and behavior of a protein called p53. Defective versions of p53 are associated with more human cancers than any other malfunctioning protein.
The goal of Amaro’s work is to find ways to restore the function of defective p53 protein in cancer cells. Her research team at the University of California, San Diego, discovered how to do just    that—according to their computer models, at least—by fitting small molecules into a pocket in malfunctioning p53 proteins. Amaro founded a biotechnology company to bring this computational work closer to a real cure for cancer.
NIGMS has supported Amaro’s work since 2006 under P41GM103426U01GM111528R25GM114821, and F32GM077729.

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