domingo, 25 de noviembre de 2018

Clinicopathological features of breast cancer in Japanese female patients with Lynch syndrome. - PubMed - NCBI

Clinicopathological features of breast cancer in Japanese female patients with Lynch syndrome. - PubMed - NCBI



 2018 Nov 16. doi: 10.1007/s12282-018-0931-z. [Epub ahead of print]

Clinicopathological features of breast cancer in Japanese female patients with Lynch syndrome.

Abstract

BACKGROUND:

Lynch syndrome (LS) is a predominantly inherited syndrome caused by a pathological germline mutation in one of the mismatch repair (MMR) genes. Whether breast cancer (BC) is one of the LS-associated tumors is controversial. The aim of this retrospective cohort study was to evaluate the clinical features of BC in Japanese patients with LS.

METHODS:

Of 38 mutation carriers, 4 females with BC were examined in this study.

RESULTS:

Two of the four patients had multiple BC. Their median age at the diagnosis of BC was 63 (range, 47-84) years. The TNM (6th revision) stages of the six BCs were as follows: stage I, 33% (2/6); stage IIA, 50% (3/6); and stage IIB, 17% (1/6). Histological examination revealed four scirrhous, one papillotubular, and one medullary carcinoma. The positive ratios for estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth receptor 2 (HER2) were 83.3% (5/6), 83.3% (5/6), and 16.7% (1/6), respectively. Two of the three specimens showed MSI-H and one showed MSS. These MSI-H BCs had tumor-infiltrating lymphocytes. Two of the three specimens showed an absence of MLH1 and PMS2 proteins on immunohistochemistry. The cumulative risks for a person with LS to develop BC were 4.35% at the age of 50 years, 8.70% at 60 years, and 21.5% at 70 years.

CONCLUSIONS:

Our study results showed BC in Japanese females with LS to be an MSI-H tumor, which was ER and PgR positive and HER2 negative.

KEYWORDS:

Breast cancer; Lynch syndrome; Mismatch repair gene

PMID:
 
30446972
 
DOI:
 
10.1007/s12282-018-0931-z

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