jueves, 29 de noviembre de 2018

Noncoding RNAs in multiple sclerosis | Clinical Epigenetics | Full Text

Noncoding RNAs in multiple sclerosis | Clinical Epigenetics | Full Text

Clinical Epigenetics

Noncoding RNAs in multiple sclerosis

Contributed equally
Clinical Epigenetics201810:149
  • Received: 1 July 2018
  • Accepted: 14 November 2018
  • Published: 


Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is characterized by axonal degeneration and gliosis. Although the causes of MS remain unknown, gene dysregulation in the central nervous system has been associated with the disease pathogenesis. As such, the various regulators of gene expression may be contributing factors. The noncoding (nc) RNAs have piqued the interest of MS researchers due to their known functions in human physiology and various pathological processes, despite being generally characterized as transcripts without apparent protein-coding capacity. Accumulating evidence has indicated that ncRNAs participate in the regulation of MS by acting as epigenetic factors, especially the long (l) ncRNAs and the micro (mi) RNAs, and they are now recognized as key regulatory molecules in MS. In this review, we summarize the most current studies on the contribution of ncRNAs in MS pathogenic processes and discuss their potential applications in the diagnosis and treatment of MS.


  • ncRNAs
  • lncRNAs
  • miRNAs
  • circRNAs
  • Multiple sclerosis

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