Influenza viruses

Section Editor: Hualan Chen, Chinese Academy of Agricultural Sciences, China
Deputy Section Editor: Chengjun Li, Chinese Academy of Agricultural Sciences, China

The Influenza viruses section of Virology Journal will publish articles on all aspects of influenza virus research, including molecular genetics, molecular biology, biochemistry, biophysics, structural biology, cell biology, immunology, morphology, and pathogenesis. The section will also welcome the case reports of influenza outbreaks in both human and animal populations, and development and evaluation of vaccines and antiviral compounds in humans and animals.

Content Type:Research
Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway
Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strain...
Authors:Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang and Yuhuan Li
Citation:Virology Journal 2018 15:88
Published on: 21 May 2018
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Content Type:Research
Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses
With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the ...
Authors:Tessa Slater, Isabella Eckerle and Kin-Chow Chang
Citation:Virology Journal 2018 15:68
Published on: 10 April 2018
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Content Type:Research
Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens
Non-structural protein NS1 of influenza A viruses harbours several determinants of pathogenicity and host-range. However it is still unclear to what extent each of its two structured domains (i.e. RNA-binding ...
Authors:Sascha Trapp, Denis Soubieux, Alexandra Lidove, Evelyne Esnault, Adrien Lion, Vanaique Guillory, Alan Wacquiez, Emmanuel Kut, Pascale Quéré, Thibaut Larcher, Mireille Ledevin, Virginie Nadan, Christelle Camus-Bouclainville and Daniel Marc
Citation:Virology Journal 2018 15:55
Published on: 27 March 2018
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Content Type:Research
Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication
The influenza A virus non-structural protein 1 (NS1) is a multifunctional protein that plays an important role in virus replication, virulence and inhibition of the host antiviral immune response. In the avian...
Authors:Jinghua Cheng, Chunling Zhang, Jie Tao, Benqiang Li, Ying Shi and Huili Liu
Citation:Virology Journal 2018 15:57
Published on: 27 March 2018
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Content Type:Review
Towards a universal influenza vaccine: different approaches for one goal
Influenza virus infection is an ongoing health and economic burden causing epidemics with pandemic potential, affecting 5–30% of the global population annually, and is responsible for millions of hospitalizati...
Authors:Giuseppe A. Sautto, Greg A. Kirchenbaum and Ted M. Ross
Citation:Virology Journal 2018 15:17
Published on: 19 January 2018
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Content Type:Research
Production of highly and broad-range specific monoclonal antibodies against hemagglutinin of H5-subtype avian influenza viruses and their differentiation by mass spectrometry
The highly pathogenic avian influenza viruses of the H5 subtype, such as the H5N1 viral strains or the novel H5N8 and H5N2 reassortants, are of both veterinary and public health concern worldwide. To combat th...
Authors:Violetta Sączyńska, Anna Bierczyńska-Krzysik, Violetta Cecuda-Adamczewska, Piotr Baran, Anna Porębska, Katarzyna Florys, Marcin Zieliński and Grażyna Płucienniczak
Citation:Virology Journal 2018 15:13
Published on: 15 January 2018
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Content Type:Methodology
Molecular subtyping of European swine influenza viruses and scaling to high-throughput analysis
Swine influenza is a respiratory infection of pigs that may have a significant economic impact in affected herds and pose a threat to the human population since swine influenza A viruses (swIAVs) are zoonotic ...
Authors:Emilie Bonin, Stéphane Quéguiner, Cédric Woudstra, Stéphane Gorin, Nicolas Barbier, Timm C. Harder, Patrick Fach, Séverine Hervé and Gaëlle Simon
Citation:Virology Journal 2018 15:7
Published on: 10 January 2018
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Content Type:Research
Bacterial ribonuclease binase exerts an intra-cellular anti-viral mode of action targeting viral RNAs in influenza a virus-infected MDCK-II cells
Influenza is a severe contagious disease especially in children, elderly and immunocompromised patients. Beside vaccination, the discovery of new anti-viral agents represents an important strategy to encounter...
Authors:Raihan Shah Mahmud, Ahmed Mostafa, Christin Müller, Pumaree Kanrai, Vera Ulyanova, Yulia Sokurenko, Julia Dzieciolowski, Irina Kuznetsova, Olga Ilinskaya and Stephan Pleschka
Citation:Virology Journal 2018 15:5
Published on: 5 January 2018
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Content Type:Research
Single-walled carbon nanotubes modulate pulmonary immune responses and increase pandemic influenza a virus titers in mice
Numerous toxicological studies have focused on injury caused by exposure to single types of nanoparticles, but few have investigated how such exposures impact a host’s immune response to pathogen challenge. Fe...
Authors:Hao Chen, Xiao Zheng, Justine Nicholas, Sara T. Humes, Julia C. Loeb, Sarah E. Robinson, Joseph H. Bisesi Jr, Dipesh Das, Navid B. Saleh, William L. Castleman, John A. Lednicky and Tara Sabo-Attwood
Citation:Virology Journal 2017 14:242
Published on: 22 December 2017
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Content Type:Research
Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population
IFITM3 has been suggested to be associated with infection in some ethnic groups. Diabetes and hypercholesterolemia are also important clinical conditions that can predispose individual...
Authors:Parvaneh Mehrbod, Sana Eybpoosh, Fatemeh Fotouhi, Hadiseh Shokouhi Targhi, Vahideh Mazaheri and Behrokh Farahmand
Citation:Virology Journal 2017 14:218
Published on: 9 November 2017
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Content Type:Research
Investigation of antiviral state mediated by interferon-inducible transmembrane protein 1 induced by H9N2 virus and inactivated viral particle in human endothelial cells
Endothelial cells are believed to play an important role in response to virus infection. Our previous microarray analysis showed that H9N2 virus infection and inactivated viral particle inoculation increased t...
Authors:Bo Feng, Lihong Zhao, Wei Wang, Jianfang Wang, Hongyan Wang, Huiqin Duan, Jianjun Zhang and Jian Qiao
Citation:Virology Journal 2017 14:213
Published on: 3 November 2017
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Content Type:Research
Characteristics of influenza H13N8 subtype virus firstly isolated from Qinghai Lake Region, China
Since the highly pathogenic H5N1 influenza caused thousands of deaths of wild bird in this area in 2005, Qinghai Lake in China has become a hot spot for study of the influence of avian influenza to migratory w...
Authors:Jie Dong, Hong Bo, Ye Zhang, Libo Dong, Shumei Zou, Weijuan Huang, Jia Liu, Dayan Wang and Yuelong Shu
Citation:Virology Journal 2017 14:180
Published on: 18 September 2017
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Content Type:Research
Effective usage of cationic derivatives of polyprenols as carriers of DNA vaccines against influenza virus
Cationic derivatives of polyprenols (trimethylpolyprenylammonium iodides – PTAI) with variable chain length between 6 and 15 isoprene units prepared from naturally occurring poly-cis-prenols were tested as DNA va...
Authors:Anna Stachyra, Monika Rak, Patrycja Redkiewicz, Zbigniew Madeja, Katarzyna Gawarecka, Tadeusz Chojnacki, Ewa Świeżewska, Marek Masnyk, Marek Chmielewski, Agnieszka Sirko and Anna Góra-Sochacka
Citation:Virology Journal 2017 14:168
Published on: 2 September 2017
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Content Type:Short Report
Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection
Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010–2011 influenza seasons, nearly half o...
Authors:Julie McAuley, Yi-Mo Deng, Brad Gilbertson, Charley Mackenzie-Kludas, Ian Barr and Lorena Brown
Citation:Virology Journal 2017 14:162
Published on: 22 August 2017
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Content Type:Research
Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA
Defective interfering (DI) viruses are natural antivirals made by nearly all viruses. They have a highly deleted genome (thus being non-infectious) and interfere with the replication of genetically related inf...
Authors:Bo Meng, Kirsten Bentley, Anthony C. Marriott, Paul D. Scott, Nigel J. Dimmock and Andrew J. Easton
Citation:Virology Journal 2017 14:138
Published on: 24 July 2017
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Content Type:Short Report
Real-time reverse transcription PCR-based sequencing-independent pathotyping of Eurasian avian influenza A viruses of subtype H7
Low pathogenic avian influenza viruses (LPAIV) of the subtypes H5 and H7 are known to give rise to highly pathogenic (HP) phenotypes by spontaneous insertional mutations which convert a monobasic trypsin-sensi...
Authors:Annika Graaf, Martin Beer and Timm Harder
Citation:Virology Journal 2017 14:137
Published on: 24 July 2017
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Content Type:Research
Avian influenza H9N2 virus isolated from air samples in LPMs in Jiangxi, China
Recently, avian influenza virus has caused repeated worldwide outbreaks in humans. Live Poultry Markets (LPMs) play an important role in the circulation and reassortment of novel Avian Influenza Virus (AIVs). ...
Authors:Xiaoxu Zeng, Mingbin Liu, Heng Zhang, Jingwen Wu, Xiang Zhao, Wenbing Chen, Lei Yang, Fenglan He, Guoyin Fan, Dayan Wang, Haiying Chen and Yuelong Shu
Citation:Virology Journal 2017 14:136
Published on: 24 July 2017
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Content Type:Research
Semi-quantitative Influenza A population averages from a multiplex respiratory viral panel (RVP): potential for reflecting target sequence changes affecting the assay
Yearly influenza virus mutations potentially affect the performance of molecular assays, if nucleic acid changes involve the sequences in the assay. Because individual patient viral loads depend on variables s...
Authors:Kenneth H. Rand, Maura Pieretti, Rodney Arcenas, Stacy G. Beal, Herbert Houck, Emma Boslet and John A. Lednicky
Citation:Virology Journal 2017 14:128
Published on: 14 July 2017
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Content Type:Research
Maternal antibodies protect offspring from severe influenza infection and do not lead to detectable interference with subsequent offspring immunization
Various studies have shown that infants under the age of 6 months are especially vulnerable for complications due to influenza. Currently there are no vaccines licensed for use in this age group. Vaccination o...
Authors:Joan E. M. van der Lubbe, Jessica Vreugdenhil, Sarra Damman, Joost Vaneman, Jaco Klap, Jaap Goudsmit, Katarina Radošević and Ramon Roozendaal
Citation:Virology Journal 2017 14:123
Published on: 26 June 2017
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Content Type:Short Report
Chorioallantoic membranes of embryonated chicken eggs as an alternative system for isolation of equine influenza virus
Influenza virus isolation in embryonated chicken eggs (ECEs) is not applicable for rapid diagnosis, however it allows the recovery and propagation of the viable virus. A low number of infectious virus particle...
Authors:Ilona Marcelina Gora, Malgorzata Kwasnik, Jan Franciszek Zmudzinski and Wojciech Rozek
Citation:Virology Journal 2017 14:120
Published on: 21 June 2017
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