The personal and clinical utility of polygenic risk scores.

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Last Posted: May 24, 2018

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• The personal and clinical utility of polygenic risk scores.  
  Torkamani Ali et al. Nature reviews. Genetics 2018 May
• Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative  
  LG Fritsche et al, AJHG, May 2018
• Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease.  
  Kauppi Karolina et al. Frontiers in neuroscience 2018 12260
• Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtype  
  MS Udler et al, BioRXIV, May 2018
• Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry.  
  Iribarren Carlos et al. Scientific reports 2018 May 8(1) 6853
• Genome Culture: A Personal Risk Score May Be the Next Big Thing in Genetic Medicine  
  L Hercher, Genome Magazine, Apr 2018
• Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study.  
  Tikkanen Emmi et al. Circulation 2018 Apr
• Cardiovascular Genetic Risk Testing for Targeting Statin Therapy in the Primary Prevention of Atherosclerotic Cardiovascular Disease: A Cost-Effectiveness Analysis.  
  Jarmul Jamie et al. Circulation. Cardiovascular quality and outcomes 2018 Apr 11(4) e004171
• Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study  
  E Tikanen et al, Circulation, Apr 10, 2018
• Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts.  
  J Ward et al, BioRXIV, Apr 2018

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