Front Oncol. 2018 May 4;8:144. doi: 10.3389/fonc.2018.00144. eCollection 2018.
Precision Medicine in Hormone Receptor-Positive Breast Cancer.
Nasrazadani A1, Thomas RA1, Oesterreich S2, Lee AV2.
In recent decades, breast cancer has become largely manageable due to successes with hormone receptor targeting. Hormone receptor-positive tumors have favorable outcomes in comparison to estrogen receptor (ESR1, ER)/progesterone receptor-negative tumors given the targetable nature of these tumors, as well as their inherently less aggressive character. Nonetheless, treatment resistance is frequently encountered due to a variety of mechanisms, including ESR1 mutations and loss of ER expression. A new era of precision medicine utilizes a range of methodologies to allow real-time analysis of individual genomic signatures in metastases and liquid biopsies with the goal of finding clinically actionable targets. Preliminary studies have shown improved progression-free survival and overall survival with implementation of this information for clinical decision making. In this review, we will discuss the opportunities and challenges in integrating precision medicine through next-generation genomic sequencing into the management of breast cancer.
circulating tumor DNA; circulating tumor cells; hormone receptor-positive breast cancer; liquid biopsy; personalized medicine
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