CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer. - PubMed - NCBI

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer. - PubMed - NCBI

Cell Syst. 2017 Jul 11. pii: S2405-4712(17)30230-2. doi: 10.1016/j.cels.2017.06.002. [Epub ahead of print]

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.

Bridgett S1, Campbell J2, Lord CJ2, Ryan CJ3.

Author information

Abstract

Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.

Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

CRISPR; RNAi; cancer; genetic interactions; network biology; precision medicine; synthetic lethality

PMID:

 

28711281

 

DOI:

 

10.1016/j.cels.2017.06.002

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