Genomics & Health Impact Scan Database|Weekly Scan|PHGKB
Publication Date: Jun 22, 2017
About the Genomics & Health Impact Weekly Scan
This weekly update features emerging roles of human genomics, testing and interventions in a wide variety of noncommunicable diseases across the life span, including, birth defects, newborn screening, reproductive health, childhood diseases, cancer, chronic diseases, pharmacogenomics, family health history, guidelines and recommendations. The weekly sweep also includes news, reviews, commentaries, tools and databases.
Human Genomics across the Lifespan
Birth Defects and Child Health
- Clinical use of the Oncotype DX genomic test to guide treatment decisions for patients with invasive breast cancer.
McVeigh Terri P et al. Breast cancer (Dove Medical Press) 2017 9393-400
- Predictability of BRCA1/2 mutation status in patients with ovarian cancer: How to select women for genetic testing in middle-income countries.
Teixeira Natalia et al. Maturitas 2017 Jun
- Acceptance of adjuvant chemotherapy recommendations in early-stage hormone-positive breast cancer.
Marcinkowski Emily F et al. The Journal of surgical research 2017 Jun 21479-85
- A universal genetic testing initiative for patients with high-grade, non-mucinous epithelial ovarian cancer and the implications for cancer treatment.
Bednar Erica M et al. Gynecologic oncology 2017 Jun
- Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries.
Brédart Anne et al. Familial cancer 2017 Jun
- Pattern recognition for predictive, preventive, and personalized medicine in cancer.
Cheng Tingting et al. The EPMA journal 2017 Mar 8(1) 51-60
- Precision Oncology: Gene Changes Predict Immunotherapy Response
NIH Director Blog, June 20, 2017
- Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment.
Liede Alexander et al. Breast cancer research and treatment 2017 Jun
- Von Hippel-Lindau and Hereditary Pheochromocytoma/Paraganglioma Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Rednam Surya P et al. Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 23(12) e68-e75
- PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Schultz Kris Ann P et al. Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 23(12) e76-e82
- Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk.
Villani Anita et al. Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 23(12) e83-e90
- Impact of a 31-gene Expression Profiling Test for Cutaneous Melanoma on Dermatologists' Clinical Management Decisions.
Farberg Aaron S et al. Journal of drugs in dermatology : JDD 2017 May 16(5) 428-431
- Predictors of BRCA1/2 genetic testing among Black women with breast cancer: a population-based study.
Jones Tarsha et al. Cancer medicine 2017 Jun
- Does personalised melanoma genomic risk information trigger conversations about skin cancer prevention and skin examination with family, friends and health professionals?
Smit A K et al. The British journal of dermatology 2017 Jun
- Genetic counseling for hereditary cancer: A primer for NPs.
et al. The Nurse practitioner 2017 Jul 42(7) 28-29
- Where cigarette smoking's damage is done... down to your DNA
Science Magazine, June 12, 2017
- Do online prognostication tools represent a valid alternative to genomic profiling in the context of adjuvant treatment of early breast cancer? A systematic review of the literature.
El Hage Chehade Hiba et al. American journal of surgery 2017 Jun
- Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers.
Kuchenbaecker Karoline B et al. JAMA 2017 Jun 317(23) 2402-2416
- Do What I Couldn't...and Go Save Your Life
Amy B Shainman, June, 2017
- Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA)
The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) is a computer program that is used to calculate the risks of breast and ovarian cancer in women based on their family history.
- PARP Inhibitor for Metastatic Breast Cancer
NEJM Journal Watch, June 14, 20
- FDA Approves Pembrolizumab for Tumors with Specific Genetic Features
NCI, June 20, 2017
- The Efficacy of Genetic Counseling for Psychiatric Disorders: a Meta-Analysis.
Moldovan Ramona et al. Journal of genetic counseling 2017 Jun
- Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.
Liu Ruixin et al. Nature medicine 2017 Jun
- Is the atopic march related to confounding by genetics and early life environment? A systematic review of sibship and twin data.
Khan Sabria J et al. Allergy 2017 Jun
- ATTITUDES TOWARD GENETIC COUNSELING AND TESTING IN PATIENTS WITH INHERITED ENDOCRINOPATHIES.
Gallagher Thomas M et al. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2017 Jun
- Scientists Discover a Key to a Longer Life in Male DNA
C Zimmer, New York Times, June 16, 2017
- An online tool to help you decide whether or not to get tested to learn your genetic risk for late-onset Alzheimer's disease.
- Genes and the environment? Factors, patterns that lead to childhood obesity risk
Science Mag, June 16, 2017
- A Couple's Quest To Stop A Rare Disease Before It Takes One Of Them
NPR, All Things Considered, June 19, 2019
- Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.
Giuliani Cristina et al. Mechanisms of ageing and development 2017 Feb
- ASH Announces Upcoming Sickle Cell Disease Guidelines,
by Mathew Shanley, Rare DR, June 19, 2017
Disclaimer: Articles listed in Health Impact Weekly Scan are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- The Upside of Bad Genes,
by Moises Velasquez-Manoff, The New York Times, June 17, 2017
- This Study Is Forcing Scientists To Rethink The Human Genome,
by Kristen V. Brown, Gizmodo, June 17, 2017
- New concerns raised over value of genome-wide disease studies,
by Ewen Callaway, Nature, June 15, 2017
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