domingo, 8 de mayo de 2016

Prognostic significance of cancer family history for patients with gastric cancer: a single center experience from China. - PubMed - NCBI

Prognostic significance of cancer family history for patients with gastric cancer: a single center experience from China. - PubMed - NCBI



 2016 Apr 26. doi: 10.18632/oncotarget.9032. [Epub ahead of print]

Prognostic significance of cancer family history for patients with gastric cancer: a single center experience from China.

Liu X1,2Cai H1,2Yu L2,3Huang H1,2Long Z1,2Wang Y1,2.

Abstract

Family history of cancer is a risk factor for gastric cancer. In this study, we investigated the prognoses of gastric cancer patients with family history of cancer. A total of 1805 gastric cancer patients who underwent curative gastrectomy from 2000 to 2008 were evaluated. The clinicopathologic parameters and prognoses of gastric cancer patients with a positive family history (PFH) of cancer were compared with those with a negative family history (NFH). Of 1805 patients, 382 (21.2%) patients had a positive family history of cancer. Positive family history of cancer correlated with younger age, more frequent alcohol and tobacco use, worse differentiation, smaller tumor size, and more frequent tumor location in the lower 1/3 of the stomach. The prognoses of patients with a positive family history of cancer were better than that of patients with a negative family history. Family history of cancer independently correlated with better prognosis after curative gastrectomy in gastric cancer patients.

KEYWORDS:

cancer family history; gastric cancer; prognosis

PMID:
 
27127887
 
[PubMed - as supplied by publisher] 
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