lunes, 7 de diciembre de 2015

Representativeness of Tuberculosis Genotyping Surveillance in the United States, 2009-2010. - PubMed - NCBI

Representativeness of Tuberculosis Genotyping Surveillance in the United States, 2009-2010. - PubMed - NCBI



 2015 Nov-Dec;130(6):596-601.

Representativeness of Tuberculosis Genotyping Surveillance in the United States, 2009-2010.

Abstract

Genotyping of Mycobacterium tuberculosis isolates contributes to tuberculosis (TB) control through detection of possible outbreaks. However, 20% of U.S. cases do not have an isolate for testing, and 10% of cases with isolates do not have a genotype reported. TB outbreaks in populations with incomplete genotyping data might be missed by genotyping-based outbreak detection. Therefore, we assessed the representativeness of TB genotyping data by comparing characteristics of cases reported during January 1, 2009-December 31, 2010, that had a genotype result with those cases that did not. Of 22,476 cases, 14,922 (66%) had a genotype result. Cases without genotype results were more likely to be patients <19 years of age, with unknown HIV status, of female sex, U.S.-born, and with no recent history of homelessness or substance abuse. Although cases with a genotype result are largely representative of all reported U.S. TB cases, outbreak detection methods that rely solely on genotyping data may underestimate TB transmission among certain groups.

PMID:
 
26556930
 
[PubMed - in process] 
PMCID:
 
PMC4612167
 [Available on 2016-11-01]

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