12/02/2015
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| Immune checkpoint inhibitor; the panel on the left shows the binding of proteins B7-1/B7-2 (on the tumor cell) to CTLA-4 (on the T cell), which keeps T cells from killing tumor cells in the body. Also shown are a tumor cell antigen and T cell receptor. The panel on the right shows immune checkpoint inhibitors (anti-B7-1/B7-2 and anti-CTLA-4) blocking the binding of B7-1/B7-2 to CTLA-4, which allows the T cells to kill tumor cells. Immune checkpoint inhibitor. Certain proteins, such as CTLA-4 and B7-1/B7-2, are found on immune system cells and some tumor cells. CTLA-4 and B7-1/B7-2 help keep immune responses in check. The binding of B7-1/B7-2 (on tumor cells) to CTLA-4 (on T cells) keeps T cells from killing tumor cells in the body (left panel). Blocking the binding of B7-1/B7-2 to CTLA-4 with an immune checkpoint inhibitor (anti-B7-1/B7-2 or anti-CTLA-4) allows the T cells to kill tumor cells (right panel). |
| Title: | Immune Checkpoint Inhibitor (CTLA-4) |
|---|---|
| Description: | Immune checkpoint inhibitor; the panel on the left shows the binding of proteins B7-1/B7-2 (on the tumor cell) to CTLA-4 (on the T cell), which keeps T cells from killing tumor cells in the body. Also shown are a tumor cell antigen and T cell receptor. The panel on the right shows immune checkpoint inhibitors (anti-B7-1/B7-2 and anti-CTLA-4) blocking the binding of B7-1/B7-2 to CTLA-4, which allows the T cells to kill tumor cells. Immune checkpoint inhibitor. Certain proteins, such as CTLA-4 and B7-1/B7-2, are found on immune system cells and some tumor cells. CTLA-4 and B7-1/B7-2 help keep immune responses in check. The binding of B7-1/B7-2 (on tumor cells) to CTLA-4 (on T cells) keeps T cells from killing tumor cells in the body (left panel). Blocking the binding of B7-1/B7-2 to CTLA-4 with an immune checkpoint inhibitor (anti-B7-1/B7-2 or anti-CTLA-4) allows the T cells to kill tumor cells (right panel). |
| Topics/Categories: | Cells or Tissue -- Abnormal Cells or Tissue Cells or Tissue -- Normal Cells or Tissue |
|---|---|
| Type: | Color, Medical Illustration |
| Source: | National Cancer Institute |
| Creator: | Terese Winslow (Illustrator) |
| AV Number: | CDR776560 |
| Date Created: | November 11, 2015 |
| Date Added: | 12/2/2015 |
| Reuse Restrictions: | Yes - This image is copyright protected. Any use of this image is subject to prevailing copyright laws. U.S. Government has reuse rights. Please contact the rights holder of this image for permission requests. Rights holder: Terese Winslow Email: terese@teresewinslow.com |
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